ID M3Y3T7_MUSPF Unreviewed; 1271 AA.
AC M3Y3T7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSMPUP00000005988.1};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSMPUP00000005988.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005988.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR EMBL; AEYP01062725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Y3T7; -.
DR STRING; 9669.ENSMPUP00000005988; -.
DR Ensembl; ENSMPUT00000006093.1; ENSMPUP00000005988.1; ENSMPUG00000006039.1.
DR eggNOG; KOG1449; Eukaryota.
DR GeneTree; ENSGT00940000155110; -.
DR HOGENOM; CLU_009183_0_0_1; -.
DR InParanoid; M3Y3T7; -.
DR OMA; SYGIREQ; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF10; GTPASE-ACTIVATING PROTEIN CDGAPR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 193..255
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 322..517
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..778
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1193
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 136073 MW; 6B52F6EAE0738303 CRC64;
MGWRGTEPRA RSTDSLDGPG EGSVQPLPHT GGPSVKGKPG KRLSAPRGPF PRLADCAHFH
YENVDFGHIQ LLLSPEREGP SFSGENELVF GVQVTCQGRS WPVLRSYDDF RSLDAHLHRC
IFDRRFSCLP ELPPPPEGAR AAQMLVPLLL QYLETLSGLV DSNLNCGPVL TWMELDNHGR
RLLLSEEASL NIPAVAAAHV IKRYTAQAPD ELSFEVGDIV SVIDMPPTED RSWWRGKRGF
QVGFFPSECV ELFTERPGPG LKGEADGAQC GVPTPQGVSS LTSAVPRPRG KLAGLLRTFM
RSRPSRQRLR QRGILRQRVF GCDLGEHLSN SGQDVPQVLR CCSEFIEAHG VVDGIYRLSG
VSSNIQRLRH EFDSERIPEL SGPAFLQDIH SVSSLCKLYF RELPNPLLTY QLYGKFSEAM
SVPGEEERLV RVHDVIQQLP PPHYRTLEYL LRHLARMARH SANTSMHARN LAIVWAPNLL
RSMELESVGL GGAAAFREVR VQSVVVEFLL THVDVLFSDT FTSAGLDPAG RCLLPRPKSL
AGSGPSTRLL TLEEAQARTQ GRLGTPTEPT TPKAPASPVE RRKGERGEKQ RKPGGSSWKT
FFALGRGPSI PRKKPLPWLG GTRAPPQPSG GRPDTVTLRS AKSEESLSSQ ASGAGLQRLH
RLRRPHSSSD AFPVGPAPAG SCESLSSSSS SSESSSSSES SSSGSSAAGL AALSGSPSHR
TSAWLDDGDE LDFSPPRCLE GLRGLDFDPL TFRCSSPTPG DPAPPASPAP PAPASAFPPK
VTPQALSPRG AASPASPTAL DISEPLAVSV PPAVLELLGA GGTPASVTPT PALSPNPGLR
PHLIPLLLRG AEAQLSDTCQ QEICSKLALP VPRGAPGQHG PGMDSPLLPP PLSLLRPGGA
PPPPPKNPAR LMALALAERA QQVAQRQSQQ EHGSTPSAPH SPFHRSLSLE VGSEPPGTSG
VGPAPNSLAH SGAWVPGPPP SLPRQQSDGS LVRNQRPPGT SRRALRGPAQ VPTPGFFSSA
PRECLPPFLG VPKPGLYPLG SPSFQPSSPA PVWRSPLGPP APLDRGENLY YEIETGEGTP
YSGPTRSWSP FRSMPPDRLN ASYGLLGQSP PLHRSPDFLL SYPPPPSCFP HDHLGYSAPQ
HPTRRPTRPE PLYVNLALGP RGPSPASSSS SSPPAHPRSR SDPGPPAPRL PQKQRAPWGP
HTPHRVPAPW GPPEPLLLYR AAPPAYGRGG EHHRGSLYRN GGQGREGAGP PPPYPTPSWS
LHSEGQTRSY C
//
