ID M3Y5M4_MUSPF Unreviewed; 531 AA.
AC M3Y5M4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Keratin 4 {ECO:0000313|Ensembl:ENSMPUP00000006625.1};
DE SubName: Full=Keratin, type II cytoskeletal 4 {ECO:0000313|RefSeq:XP_004774732.1};
GN Name=KRT4 {ECO:0000313|Ensembl:ENSMPUP00000006625.1,
GN ECO:0000313|RefSeq:XP_004774732.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006625.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000006625.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004774732.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004774732.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AEYP01084487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004774732.1; XM_004774675.3.
DR STRING; 9669.ENSMPUP00000006625; -.
DR Ensembl; ENSMPUT00000006738.1; ENSMPUP00000006625.1; ENSMPUG00000006679.1.
DR GeneID; 101693833; -.
DR KEGG; mpuf:101693833; -.
DR CTD; 3851; -.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR GeneTree; ENSGT00940000161550; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR OMA; LMQDSVE; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF3; KERATIN, TYPE II CYTOSKELETAL 4; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 146..459
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 150..284
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 343..437
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 531 AA; 56959 MW; B760EC739B786DCD CRC64;
MIARQQCVRG RSRGFSCGSA VVGGGKRAAF SSFSVSGGTG RCSSGGFGSR SLYNLGGRKS
IAISMAGSRQ GAGFGSAGGF GPGSFGAGFG AGNFGSGFGG SFSGRGGPAF PACPAGGIQE
VTINQSLLTP LHVEIDPEIQ KVRTEEREQI KTLNNKFASF IDKVRFLEQQ NKVLETKWNL
LQQQTTTTSS KNLEPLFEAY ISALRKQLDT LVNDKGRLQS ELKTTQDSVE DFKTKYEDEI
NKRAAAENDF VVLKKDVDAA YMSKVELEAK VDALNDEINF LRVLFAAELS QMQTHVSDTS
VVLSMDNNRD LDLDSIIAEV RAQYEEIAQK SKAEAEALYQ TKVQQLQISV DQHGDNLKNT
KSEISELNRL IQRLRAEIEN VKKQCQTLQA SVADAEQRGE LALKDAYSKC TELETALQKA
KEELARMLRE YQELLSVKLA LDVEIATYRK LLEGEECRMS GERQSAMSIS VVSGGASTGG
IGGGLGSCSG FGLGSGFGSG SGSGFGFGGG VCGSSGSKII STTTMTKRSH R
//
