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Database: UniProt
Entry: M3Y5W6_MUSPF
LinkDB: M3Y5W6_MUSPF
Original site: M3Y5W6_MUSPF 
ID   M3Y5W6_MUSPF            Unreviewed;       481 AA.
AC   M3Y5W6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-MAY-2019, entry version 32.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL4 {ECO:0000313|Ensembl:ENSMPUP00000006717};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006717, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000006717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000006717};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000006717}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AEYP01009357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004742057.1; XM_004742000.2.
DR   STRING; 9668.ENSMPUP00000006717; -.
DR   Ensembl; ENSMPUT00000006830; ENSMPUP00000006717; ENSMPUG00000006771.
DR   GeneID; 101681380; -.
DR   CTD; 23553; -.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; M3Y5W6; -.
DR   OMA; CHNYNVY; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0030207; P:chondroitin sulfate catabolic process; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   ACT_SITE    147    147       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    368    368       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     59    351       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    223    237       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    376    387       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    381    435       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    437    446       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   481 AA;  54537 MW;  0B2695E3C8F7E915 CRC64;
     MKVLSEGQLR FCAVQPIHLT SWLLILFILK SISSLKPARL PIYQRKPFIA AWNAPTDQCL
     VKYNIGLNLK MFQVIGSPLA KARGQNVTIF YVNRLGYYPW YTSQGVPING GLPQNISLQV
     HLEKADQDIN YYIPAEDFSG LAVIDWEYWR PQWARNWNTK DVYRQKSRKL ISDMQENISA
     TDIEYLAKAT FEESAKAFMK ETIELGMRSR PKGLWGYYLY PDCHNYNVYA PNYTGSCPEE
     EVLRNNELSW LWNSSAALYP SIGVRKSLGD NENILLFSQF RVHESLRIST MTSHDYALPV
     FVYTRLGYRN EPLFFLSKQD LISTIGESAA LGAAGIVIWG DMNLTSSEGN CTKVKQYVSS
     DLGSYIVNVT RAAEVCSLHL CRGNGRCRRR VWKAPDYLHL NPASYRIEAS EDGEFIVKGK
     ASDTDLEAME KKFSCHCYRG YEGADCRGTK MADGGSRVFS FSGSLITLCL LVLAGSQRAW
     L
//
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