ID M3Y6M2_MUSPF Unreviewed; 219 AA.
AC M3Y6M2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ras-related protein Rab-3 {ECO:0000256|RuleBase:RU367096};
GN Name=RAB3B {ECO:0000313|Ensembl:ENSMPUP00000006973.1,
GN ECO:0000313|RefSeq:XP_004774530.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006973.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000006973.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004774530.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004774530.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000256|ARBA:ARBA00025673, ECO:0000256|RuleBase:RU367096}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU367096}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU367096};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU367096}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367096}.
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DR EMBL; AEYP01084271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004774529.1; XM_004774472.1.
DR RefSeq; XP_004774530.1; XM_004774473.3.
DR RefSeq; XP_012902318.1; XM_013046864.1.
DR STRING; 9669.ENSMPUP00000006973; -.
DR Ensembl; ENSMPUT00000007088.1; ENSMPUP00000006973.1; ENSMPUG00000007029.1.
DR GeneID; 101692801; -.
DR KEGG; mpuf:101692801; -.
DR CTD; 5865; -.
DR eggNOG; KOG0093; Eukaryota.
DR GeneTree; ENSGT00940000159943; -.
DR HOGENOM; CLU_041217_10_1_1; -.
DR OMA; AICEKMS; -.
DR OrthoDB; 8685at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0098691; C:dopaminergic synapse; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0019003; F:GDP binding; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031489; F:myosin V binding; IEA:Ensembl.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; IEA:Ensembl.
DR GO; GO:0098693; P:regulation of synaptic vesicle cycle; IEA:Ensembl.
DR GO; GO:0097494; P:regulation of vesicle size; IEA:Ensembl.
DR CDD; cd01865; Rab3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR037872; Rab3.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47980; LD44762P; 1.
DR PANTHER; PTHR47980:SF22; RAS-RELATED PROTEIN RAB-3B; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU367096};
KW GTP-binding {ECO:0000256|RuleBase:RU367096};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU367096};
KW Membrane {ECO:0000256|RuleBase:RU367096};
KW Methylation {ECO:0000256|ARBA:ARBA00022481, ECO:0000256|RuleBase:RU367096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367096};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289, ECO:0000256|RuleBase:RU367096};
KW Protein transport {ECO:0000256|RuleBase:RU367096};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transport {ECO:0000256|RuleBase:RU367096}.
SQ SEQUENCE 219 AA; 24782 MW; 4EEF19A18734A869 CRC64;
MASVTDTKAG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA FVSTVGIDFK
VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWATQI
KTYSWDNAQV ILVGNKCDME EERVVPTEKG RLLAEQLGFD FFEASAKENI SVRQAFERLV
DAICDKMSDS LDTDPSVLGT SKNTRLSDTP PLLQQNCSC
//
