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Database: UniProt
Entry: M3Y6R1_MUSPF
LinkDB: M3Y6R1_MUSPF
Original site: M3Y6R1_MUSPF 
ID   M3Y6R1_MUSPF            Unreviewed;       845 AA.
AC   M3Y6R1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   31-JUL-2019, entry version 55.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000007012};
GN   Name=VAV1 {ECO:0000313|Ensembl:ENSMPUP00000007012};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007012, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007012}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000007012};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000007012}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AEYP01077317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004771673.1; XM_004771616.2.
DR   STRING; 9668.ENSMPUP00000007012; -.
DR   Ensembl; ENSMPUT00000007128; ENSMPUP00000007012; ENSMPUG00000007069.
DR   GeneID; 101673926; -.
DR   CTD; 7409; -.
DR   eggNOG; KOG2996; Eukaryota.
DR   eggNOG; ENOG410XPH6; LUCA.
DR   GeneTree; ENSGT00940000159125; -.
DR   InParanoid; M3Y6R1; -.
DR   OMA; DKRECCL; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR   GO; GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:Ensembl.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10405; SH2_Vav1; 1.
DR   CDD; cd11979; SH3_VAV1_1; 1.
DR   CDD; cd11976; SH3_VAV1_2; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR028530; Vav1.
DR   InterPro; IPR035879; VAV1_SH2.
DR   InterPro; IPR035730; VAV1_SH3_1.
DR   InterPro; IPR035729; VAV1_SH3_2.
DR   PANTHER; PTHR45818:SF2; PTHR45818:SF2; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    119       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      194    373       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      402    504       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      515    564       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      592    660       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      671    765       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      782    842       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   REGION      568    590       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    571    590       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   845 AA;  98252 MW;  7E7369087EC6ED2F CRC64;
     MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
     NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI
     AQNKGIMPFP TEEDSVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRT
     EPMPMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDIEIIFINI
     EDLLRVHTHF LKEMKEALAA PGAPTLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
     REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA VEKDSLRLAL
     DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM
     DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRENKKWTHM FLLIEDQGAQ
     GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCR ACQMLLRGTF
     YQGYRCHRCR APAHKECLGR VPPCGRHGQD LSGTMKKDKP HRRAQDKKRN ELGLPKMEVC
     QEYYGLPPPP GAFGPFLRLN PGDIVELTKA EAEQNWWEGR NTATNEVGWF PCNRVKPYVH
     GPPQDLSVHL WYAGPMERAG AESILTNRSD GTFLVRQRVK DTAEFAISIK YNVEVKHIKI
     MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RAISRPPAGS
     TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEVYGRVG WFPSNYVEED
     YSEYC
//
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