ID M3Y6T0_MUSPF Unreviewed; 893 AA.
AC M3Y6T0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Adhesion G protein-coupled receptor E1 {ECO:0000313|Ensembl:ENSMPUP00000007031.1};
GN Name=ADGRE1 {ECO:0000313|Ensembl:ENSMPUP00000007031.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007031.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007031.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AEYP01077319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01077320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004771676.1; XM_004771619.2.
DR AlphaFoldDB; M3Y6T0; -.
DR STRING; 9669.ENSMPUP00000007031; -.
DR Ensembl; ENSMPUT00000007148.1; ENSMPUP00000007031.1; ENSMPUG00000007088.1.
DR GeneID; 101674584; -.
DR KEGG; mpuf:101674584; -.
DR CTD; 2015; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161354; -.
DR HOGENOM; CLU_002753_3_7_1; -.
DR InParanoid; M3Y6T0; -.
DR OMA; KCRCQVG; -.
DR OrthoDB; 1114672at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15439; 7tmB2_EMR; 1.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF449; ADHESION G PROTEIN-COUPLED RECEPTOR E1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..893
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004044413"
FT TRANSMEM 607..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..66
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 78..116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 130..167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 179..220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 229..264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 609..855
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 233..243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 893 AA; 98021 MW; A89E9C557C70E804 CRC64;
MGSSSLLLFW GYCHLFFWVV FPLESMAVDV NECLDTTTCP AYATCTNTLD SYYCTCKRGF
LSSNGLTQFR GPGVTCKDID ECSQSSSKCG PHSVCRNLLG RYKCSCFPGF SSPTGNDWIP
GYPGHFSCTD VDECADPGIC PEHATCHNSP GSYSCVCNLG FESSSGNRNI QGPGETCEDV
DECARNSTLC GLDSICINTL GKYNCSCLPG FFSPAVWTPE TVEDFRCVDV DECLHMCPSN
ATCTNTPGSY FCTCSPGFAP SNGKLSFTEQ GVHCRDIDEC SQGPSPCGPN SVCTNALGSY
SCSCIGGFQP NPEGSLNFSC KRIPFKCKED VIPNNEQVQL CQVGAAVEPE HGSFCTLMNA
TFSVLDDACE NRTAEVSLKN TAESLSSVLK QTSTWSNFTK EETSALATVV LESVKSSTLA
AFLNPSANVS QTVRAEHLEI ESKIIKEGCT EENMTFHLKA KGDEMEIACS IIEETDSTGP
TGVAFVSFLG MESFLDESFF QDPQIPLANF QSKLKMKMNS RIVQGIMTGE KKDGFSDPVI
YKLENIEPKQ DFERPICVSW DTNLEGGRWT SSGCVVLEAS KTHTVCSCNR MMNLAIIMAS
GELTMEFSLY LISHVGIIIS LVCLVLAIAT FLLCRAIRNH NTYLHLHLCI CLFLAKTLFI
TGVDKTDNQM GCAIIAGFLH YLFLACFFWM LVEAVMLFLM VRNLKVVNYF SSRNIKIWYL
CAFGYGLPVV VVAVSASVQP QGYGMHNRCW LNTDRGFIWS FLGPVCAIIM INSILLTWTL
CVLRQKLSSV NAEVSTLKDT RLLTLKAFAQ LFILGCSWVL GLFQIGPMAS IMAYLFTIIN
SLQGAFIFII HCLLNRQVRE EYRRLITKKI KPSSETQSSG ILLSSVPSTS KTG
//
