ID M3Y759_MUSPF Unreviewed; 76 AA.
AC M3Y759;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Small nuclear ribonucleoprotein G {ECO:0000256|RuleBase:RU365052};
DE Short=snRNP-G {ECO:0000256|RuleBase:RU365052};
GN Name=SNRPG {ECO:0000313|RefSeq:XP_004742200.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007163.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007163.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004742200.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004742200.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays role in pre-mRNA splicing as core component of the SMN-
CC Sm complex that mediates spliceosomal snRNP assembly and as component
CC of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome. Component of both the
CC pre-catalytic spliceosome B complex and activated spliceosome C
CC complexes. Is also a component of the minor U12 spliceosome. As part of
CC the U7 snRNP it is involved in histone 3'-end processing.
CC {ECO:0000256|RuleBase:RU365052}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU365052}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365052}.
CC Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC before SMN-mediated transport to the nucleus to be included in
CC spliceosomes. {ECO:0000256|RuleBase:RU365052}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC {ECO:0000256|ARBA:ARBA00006850, ECO:0000256|RuleBase:RU365052}.
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DR EMBL; AEYP01010426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01010427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004742200.1; XM_004742143.3.
DR STRING; 9669.ENSMPUP00000007163; -.
DR Ensembl; ENSMPUT00000007282.1; ENSMPUP00000007163.1; ENSMPUG00000007221.1.
DR GeneID; 101677043; -.
DR KEGG; mpuf:101677043; -.
DR CTD; 6637; -.
DR eggNOG; KOG1780; Eukaryota.
DR GeneTree; ENSGT00510000046985; -.
DR HOGENOM; CLU_076902_10_1_1; -.
DR OMA; SKNNIGM; -.
DR OrthoDB; 5091363at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR CDD; cd01719; Sm_G; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR InterPro; IPR044641; Lsm7/SmG-like.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR001163; Sm_dom_euk/arc.
DR InterPro; IPR034098; Sm_G.
DR PANTHER; PTHR10553; SMALL NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR10553:SF26; SMALL NUCLEAR RIBONUCLEOPROTEIN G-RELATED; 1.
DR Pfam; PF01423; LSM; 1.
DR PIRSF; PIRSF037188; U6_snRNA_Lsm7; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU365052};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU365052};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU365052};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365052};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Ribonucleoprotein {ECO:0000256|RuleBase:RU365052,
KW ECO:0000313|RefSeq:XP_004742200.1};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU365052};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU365052}.
FT DOMAIN 4..76
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
SQ SEQUENCE 76 AA; 8496 MW; 623302BF6BE758FE CRC64;
MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV
VIRGNSIIML EALERV
//
