ID   M3Y7L4_MUSPF            Unreviewed;       806 AA.
AC   M3Y7L4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=GRAM domain containing 1A {ECO:0000313|Ensembl:ENSMPUP00000007321.1};
DE   SubName: Full=Protein Aster-A isoform X2 {ECO:0000313|RefSeq:XP_012918177.1};
GN   Name=GRAMD1A {ECO:0000313|Ensembl:ENSMPUP00000007321.1,
GN   ECO:0000313|RefSeq:XP_012918177.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007321.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007321.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_012918177.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_012918177.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC       Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; AEYP01062772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01062773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012918177.1; XM_013062723.2.
DR   STRING; 9669.ENSMPUP00000007321; -.
DR   Ensembl; ENSMPUT00000007441.1; ENSMPUP00000007321.1; ENSMPUG00000007379.1.
DR   GeneID; 101674177; -.
DR   KEGG; mpuf:101674177; -.
DR   CTD; 57655; -.
DR   eggNOG; KOG1032; Eukaryota.
DR   GeneTree; ENSGT00940000161007; -.
DR   HOGENOM; CLU_015189_1_0_1; -.
DR   OMA; LIVYSCA; -.
DR   OrthoDB; 45896at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044232; C:organelle membrane contact site; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF8; PROTEIN ASTER-A; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00568; GRAM; 1.
DR   PROSITE; PS51778; VAST; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        693..713
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          453..624
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  89493 MW;  BD8F4DF8A768E294 CRC64;
     MAELLSQLPW PPLAEGSTED ASVPRAKWQS QQPKGGGAEG LAHEPWRFLE VPSIYITPCS
     DGESPPCTPT PQRLQLPRTP DPDSLSQDST TPHSGRSTPS SSPSLRKRLQ LLPSSRSPPE
     PEPGTMVEKG SDSSSEKGGV PGTPSTQSLG SRNFIRNSKK MQSWYSMLSP TYKQRNEDFR
     KLFSKLPEAE RLIVDYSCAL QREILLQGRL YLSENWICFY SNIFRWETTI SIQLKEVTCL
     KKEKTAKLIP NAIQICTESE KHFFTSFGAR DRCFLLIFRL WQNALLEKTL SPRELWHLVH
     QCYGSELGLT SEDEDYVCPL QLNGLGSSKE VGDVIALSDI TPSGAADNSQ EPSPVGSRRG
     RITPNLSRAS SDADHGAEED KEEQTDSQPD ASSSQTVTPV AEPPSTEPTP PEGPTSLGPL
     DLLRSEELLT DTSNSSSSTG EEADLAALLP DLSGRLLINS VFHVGAERLQ QMLFSDSPFL
     QGFLQQCKFT DVTLSPWSGD NKCHQRRVLT YTIPISNPLG PKSASVVETQ TLFRRGPQAG
     GCVVDSEVLT QGIPYQDYFY TAHRYCILGL ARNKARLRVS SEIRYRKQPW SLVKSLIEKN
     SWSGIEDYFH HLERELAKAE KLSLEEGGKD ARTLLSGLRR RKRPLSWRGH GDGPQHPDPD
     PCARAGMHTS GSLSSRFSEP SADPGPGAGV PSALVLISVV LIVLIALNVL LFYRLWSLER
     TAHTFESWHS LALAKGKFPQ TATEWAEILA LQKQFHSVEV HKWRQILRAS VELLDEMKFS
     LEKLHQGITV SDPPFDSQPR PDDSFS
//