ID M3Y897_MUSPF Unreviewed; 603 AA.
AC M3Y897;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Sodium/potassium/calcium exchanger 4 isoform X2 {ECO:0000313|RefSeq:XP_004739091.1};
DE SubName: Full=Solute carrier family 24 member 4 {ECO:0000313|Ensembl:ENSMPUP00000007554.1};
GN Name=SLC24A4 {ECO:0000313|Ensembl:ENSMPUP00000007554.1,
GN ECO:0000313|RefSeq:XP_004739091.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007554.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007554.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004739091.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004739091.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR EMBL; AEYP01004222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01004223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01004224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01004225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01004226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01004227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004739091.1; XM_004739034.3.
DR STRING; 9669.ENSMPUP00000007554; -.
DR Ensembl; ENSMPUT00000007675.1; ENSMPUP00000007554.1; ENSMPUG00000007609.1.
DR GeneID; 101683810; -.
DR CTD; 123041; -.
DR eggNOG; KOG1307; Eukaryota.
DR GeneTree; ENSGT01030000234532; -.
DR HOGENOM; CLU_007948_5_2_1; -.
DR OMA; LFGSWGH; -.
DR OrthoDB; 22570at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0097186; P:amelogenesis; IEA:Ensembl.
DR GO; GO:1990034; P:calcium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0071486; P:cellular response to high light intensity; IEA:Ensembl.
DR GO; GO:0036368; P:cone photoresponse recovery; IEA:Ensembl.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IEA:Ensembl.
DR GO; GO:0042756; P:drinking behavior; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
DR GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0021630; P:olfactory nerve maturation; IEA:Ensembl.
DR GO; GO:0007602; P:phototransduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1903998; P:regulation of eating behavior; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1990680; P:response to melanocyte-stimulating hormone; IEA:Ensembl.
DR GO; GO:1990834; P:response to odorant; IEA:Ensembl.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF21; SODIUM_POTASSIUM_CALCIUM EXCHANGER 4; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..245
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 435..585
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 339..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 66801 MW; 393AD376BD0A7968 CRC64;
MALRGALRPR KVRRRREMLP QQVGFVCAVL ALVCCASGLL GSLGHKTASA SQRVLPDTWR
SRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD
FFVPSLEKIC EKLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN
ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TLSVIVLIAF IYDEEIVWWE GLVLIILYAF
YILIMKYNVK MQAFFTIKQK TIANGNTVNS ELEDVKEEPQ YSKNPVVMVD EVMSSSPPKF
SFPEAGLRIM ITNKFGPRTR LRMASRIIIN ERQRLINSAN GANSKPLQNG RHENIENGNV
PVENPSDPPR EQEPQPPPPP PPPEPEPIES AFLSPFSMPE ARGDKAKWVF TWPLIFLLCV
TIPNCSKPRW EKYFMVTFIT ATLWIAVFSY LMVWLVTIIG YTLGIPDVIM GITFLAAGTS
VPDCMASLIV ARQGLGDMAV SNTIGSNVFD ILVGLGIPWG LQTMVINYGS TVKINSRGLV
YSVVLLLGSV ALTVLGIHLN KWRLDRKLGI CVLALYAVFL CFSIMIEFNV FTFVNLPMCR
EDD
//
