UniProt: M3Y8C9

Database: UniProt
Entry: M3Y8C9_MUSPF

LinkDB:  M3Y8C9_MUSPF 
Original site:  M3Y8C9_MUSPF

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Ontology (8)   
   GO (8)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (10)   
   RefSeq(pep) (10)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (10)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (34)   

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ID   M3Y8C9_MUSPF            Unreviewed;       415 AA.
AC   M3Y8C9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN   Name=TRAF1 {ECO:0000313|Ensembl:ENSMPUP00000007586.1,
GN   ECO:0000313|RefSeq:XP_004775665.1, ECO:0000313|RefSeq:XP_004775666.1,
GN   ECO:0000313|RefSeq:XP_004775667.1, ECO:0000313|RefSeq:XP_004775670.1,
GN   ECO:0000313|RefSeq:XP_004775671.1, ECO:0000313|RefSeq:XP_004775672.1,
GN   ECO:0000313|RefSeq:XP_004775673.1, ECO:0000313|RefSeq:XP_004775674.1,
GN   ECO:0000313|RefSeq:XP_004775679.1, ECO:0000313|RefSeq:XP_044938263.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007586.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007586.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004775665.1, ECO:0000313|RefSeq:XP_004775666.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004775665.1,
RC   ECO:0000313|RefSeq:XP_004775666.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR015614}.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC       {ECO:0000256|PIRNR:PIRNR015614}.
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DR   EMBL; AEYP01087125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004775665.1; XM_004775608.3.
DR   RefSeq; XP_004775666.1; XM_004775609.3.
DR   RefSeq; XP_004775667.1; XM_004775610.3.
DR   RefSeq; XP_004775670.1; XM_004775613.3.
DR   RefSeq; XP_004775671.1; XM_004775614.3.
DR   RefSeq; XP_004775672.1; XM_004775615.3.
DR   RefSeq; XP_004775673.1; XM_004775616.3.
DR   RefSeq; XP_004775674.1; XM_004775617.3.
DR   RefSeq; XP_004775679.1; XM_004775622.3.
DR   RefSeq; XP_044938263.1; XM_045082328.1.
DR   STRING; 9669.ENSMPUP00000007586; -.
DR   Ensembl; ENSMPUT00000007707.1; ENSMPUP00000007586.1; ENSMPUG00000007641.1.
DR   GeneID; 101682095; -.
DR   KEGG; mpuf:101682095; -.
DR   CTD; 7185; -.
DR   eggNOG; KOG0297; Eukaryota.
DR   GeneTree; ENSGT00940000161076; -.
DR   HOGENOM; CLU_021061_0_0_1; -.
DR   OMA; CIVETNA; -.
DR   OrthoDB; 2913784at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd03779; MATH_TRAF1; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR037306; TRAF1_MATH.
DR   InterPro; IPR032070; TRAF_BIRC3-bd.
DR   InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR   PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR   PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR   Pfam; PF21355; TRAF-mep_MATH; 1.
DR   Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR   PIRSF; PIRSF015614; TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 1.
DR   PROSITE; PS50144; MATH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR015614};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR015614};
KW   Receptor {ECO:0000313|RefSeq:XP_004775665.1,
KW   ECO:0000313|RefSeq:XP_004775666.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Zinc {ECO:0000256|PIRNR:PIRNR015614}.
FT   DOMAIN          265..411
FT                   /note="MATH"
FT                   /evidence="ECO:0000259|PROSITE:PS50144"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          186..248
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   415 AA;  45861 MW;  7DC5980E8607D1BD CRC64;
     MASGPASSPR PAPDENEFPF GCPPTACQDP PEPRAPCCAA CLSGNVRTSE DQICPKCRGD
     GPQSVSPGSL QSQDKDHPEA AEAEAGCPFA SVGCSYKGSP KLLQEHEVTS QTAHLNLLLG
     FLKQRKAQQG VGLESGPMAL EQNLSDLQLQ AAVEVAGDLE VDCYRAPHAE SQDEQALKHF
     MKEKLLAELE EKLRVFENIV AVLNKEVEAS HLALAASIHQ SQLDREHILS LEQRVLELQQ
     TLAQKDQALG KLEQGLRLME EASFDGTFLW KITNVTRRCH ESACGRTVSL FSPAFYTAKY
     GYKLCLRLYL NGDGTGKRTH LSLFIVIMRG EYDALLPWPF RNKVTFMLLD QNNREHAIDA
     FRPDLSSASF QRPQSETNVA SGCPLFFPLN RLQSPKHAYV KDDTMFLKCI VETST
//

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