ID M3Y8G0_MUSPF Unreviewed; 626 AA.
AC M3Y8G0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A3 {ECO:0000313|Ensembl:ENSMPUP00000007617.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007617.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007617.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-
CC noradrenaline(in) + chloride(in) + Na(+)(in); Xref=Rhea:RHEA:70923,
CC ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:72587;
CC Evidence={ECO:0000256|ARBA:ARBA00034288};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) +
CC dopamine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70931, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:59905;
CC Evidence={ECO:0000256|ARBA:ARBA00034267};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) +
CC dopamine(in) + Na(+)(in); Xref=Rhea:RHEA:70919, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:59905;
CC Evidence={ECO:0000256|ARBA:ARBA00034275};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, axon {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A3 subfamily. {ECO:0000256|ARBA:ARBA00007836}.
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DR EMBL; AEYP01069876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01069877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Y8G0; -.
DR STRING; 9669.ENSMPUP00000007617; -.
DR Ensembl; ENSMPUT00000007738.1; ENSMPUP00000007617.1; ENSMPUG00000007672.1.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000161224; -.
DR HOGENOM; CLU_006855_9_0_1; -.
DR InParanoid; M3Y8G0; -.
DR OMA; KRWKYAG; -.
DR GO; GO:0043679; C:axon terminus; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016600; C:flotillin complex; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
DR GO; GO:0005330; F:dopamine:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
DR GO; GO:0042420; P:dopamine catabolic process; IEA:Ensembl.
DR GO; GO:1990384; P:hyaloid vascular plexus regression; IEA:Ensembl.
DR GO; GO:0007595; P:lactation; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0001504; P:neurotransmitter uptake; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0060134; P:prepulse inhibition; IEA:Ensembl.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0007608; P:sensory perception of smell; IEA:Ensembl.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002436; Na/ntran_symport_dopamine.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF38; SODIUM-DEPENDENT DOPAMINE TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01202; DOPTRANSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 78..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 69464 MW; 84931EAD0B901A86 CRC64;
ARSPRLRPPM SENKRPAAPM SSAAAPAKEP NAMGPKAVEL VLVKEQNGVQ LTNSTLANPT
QTPLGTQERE TWSKKIDFLL SVIGFAVDLA NVWRFPYLCY KNGGGAFLVP YLLFMVIAGM
PLFYMELALG QFNREGAAGV WKICPVLKGV GFTVILISLY VGFFYNVIIA WALHYFFSSF
SVDLPWVHCN NTWNSPNCSD AHAGNSSSGP NDTFRTTPAT EYFERGVLHL HESRGIDDLG
PPRWQLTSCL VLVIILLYFS LWKGVKTSGK VVWVTATMPY VVLFALLLRG ITLPGAIDGI
RAYLSVDFRR LCESSVWIDA ATQVCFSLGV GFGVLIAFSS YNKFTNNCYR DAVITTSVNS
LTSFSSGFVV FSFLGYMAQK HSVPVGDVAK DGPGLIFIIY PEALATLPLS SAWAVIFFIM
LLTLGIDSAM GGMESVITGL VDEFQLLRRH RELFTLFVVL ATFLLSLFCV TNGGIYVFTL
LDHFAAGTSI LFGVLVEAIG VAWFYGVRQF SEDIKQMTGQ RPSLYWRLCW KFVSPCFLLF
VVVVSIVTFR PPHYGAYVFP EWANALGWAI ATSSMSMVPI YAAYKFCSLP GSLREKLAYA
ITPEQERELV DSGEVRQFRL RHWLLV
//
