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Database: UniProt
Entry: M3Y9I7_MUSPF
LinkDB: M3Y9I7_MUSPF
Original site: M3Y9I7_MUSPF 
ID   M3Y9I7_MUSPF            Unreviewed;      4863 AA.
AC   M3Y9I7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMPUP00000007994};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMPUP00000007994};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007994, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007994}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000007994};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000007994}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AEYP01027985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01027994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000007994; -.
DR   Ensembl; ENSMPUT00000008119; ENSMPUP00000007994; ENSMPUG00000008052.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   InParanoid; M3Y9I7; -.
DR   OMA; PLLNEYC; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4404   4424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4469   4491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4664   4685       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4744   4767       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1465       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3911   3946       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3216   3236       {ECO:0000256|SAM:Coils}.
FT   COILED     3391   3411       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4863 AA;  551117 MW;  C1CD551019A5EB0C CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR ENATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVSNGN VQVDASFMQT LWNVHPTCSG SSVEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDAQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHIT TGHYLALTED
     QGLLLQDRTK SDTKSTAFSF RASKEIKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRAAA PVTLPIQEVL QTLQDLIAYF QPPEEEMQHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVVS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD AEGIRDLLGT
     TQSLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE VLVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
     MNLGMDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVVRID
     GTMDSPPCLK VTHKTFGTQN SNASMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTCYYA IRIFAGQDPS CVWVGWVTPD YHLYSEKFDL NKNCTVTVTL GDERGRVHES
     VKRSNCYMVW GGDIVATSQR SSRSNVDLEI GCLVDLAMGM LSFSANGREL GTCYQVEPNT
     KVFPAVFLQP TSTSLFQFEL GKLKNAMPLS AAIFKSEEKN PVPQCPPRLD VQTIQPVLWS
     RMPSSFLKVE TERVSERHGW AVQCLEPLQM MALHIPEENR CVDILELCEQ EDLMQFHYHT
     LRLYSAVCAL GNSRVAYALC GHVDLSQLFY AIDNKYLPGL LRSGFYDLLI SIHLANAKER
     KLMMKNEYII PITSATRKIR LYPDESKRHG LPGVGLRTCL KPGFRFSTPC FVVTGEEHQK
     QSPEIPLEIL KTKALSMLTE AVQHSGAHIR DPVGGSVEFQ FVPVLKLIGT LLVMGVFDDD
     DIRQILLLID PSVFGEHSVE TEDGAEKEEV TQVEEKAVEA GEKAGKEAPV RGLLQTRLPE
     SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KSRYNELMQA LNMSAALTAR
     KTREFRSPPQ EQINMLLNFQ LGENCPCPEE IREELYDFHE DLLIHCGVPL EEEEEEEEDT
     SWAGKLRALV YKIKGPPKPE KEQPTEEEEK CPTTLKELIS QTMIRWAQED QIQDAELVRM
     MFSLLQRQYD SIGELLQALR KTYTISQASV SDTINLLAAL GQIRCLFSVR MGKEEELLMI
     NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGAEK SQIAFPKMVA SCCRFLCYFC
     RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LGLEEPDLEK
     VVTYLAGCGL QSCPMLLAKG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL
     IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKREVMEDG EDEEIVHMGN
     AIMSFYSALI DLLGRCAPEM HLIQTGKGEA IRIRSILRSL VPTEDLVGII SIPLKLPSLN
     KDGSISEPDM AANFCPDHKA PMVLFLDRVY GIKDQTFLLH LLEVGFLPDL RASASLDTVS
     LSTTEAALAL NRYLCSAVLP LLTRCAPLFA GTEHYTSLVD STLQTIYRLS KGRSLTKAQR
     DTIEECLLAI CNHLRPSMLQ QLLRRLVFDV PQLNEYCKMP LKLLTNHYEQ CWKYYCLPSG
     WGSYGLAVEE ELHLTEKLFW GIFDSLSHKK YDPDLFRMAL PCLSAIAGAL PPDYLDTRIS
     ATLEKQISVD ADGNFDPKPI NTMNFSLPEK WEYIVTKYAE HSHDKWACDK SQNGWKYGIS
     LDENVKTHPL IRPFKTLTEK EKEIYRWPAR ESLKTMLAVG WSVERTKEGE AVVQQRENEK
     LRSVSQASQG NSYSPAPLDL SNVVLSRELQ GMVEVVAENY HNIWAKKKKL ELESKGGGSH
     PLLVPYDTLT AKEKFRDREK AQDLFKFLQV NGIVVSRGVK DMELDASSME KRFAYKFLKK
     ILKYVDSAQE FIAHLEAIVS SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN HHLYFLSSPL
     KPLSSSGYAS HKEKEMVASL FCKLAALVRH RISLFGSDST TMVSCLHILA QTLDTRTVMK
     SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT TVALLPILTS
     IFEHVAQHQF GVDLLLGDVQ ISCYHILCSL YSLGTGKNIY VERQRPALGE CLASLAAAIP
     VAFLEPTLNR YNPLSVFNTK TPRERSILGM PDTVEEMCPD IPQLEGLMKE ISDLAESGAR
     YTEMPHVIEV ILPMLCNYLS YWWERGPEHL PPSTGPWCTK VTSEHLSVIL GNILKIINNN
     LGIDEASWMK RIAVYAQPII SKARPDLLKS HFIPTLEKLK KKAVKTVQEE EQLKADTKGD
     TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKS PSADSDQLFR MVAEVFILWC
     KSHNFKREEQ NFVIQNEINN LAFLTGDSKS KMSKSGGQDQ ERKKTKRRGD LYSIQTSLIV
     AALKKMLPIG LNMCTPGDQE LISLAKSRYS YRDTDEEVKE HLRNNLHLQE KSDDPAVKWQ
     LNLYKDVLKS EEPFNAEKTI ERVQRISAAV FHLEQVEQPL RSKKAVWHKL LSKQRKRAVV
     ACFRMAPLYN LPRHRSINLF LHGYQRFWIE TEEYSFEEKL VQDLAKSPKV EEEEEEEMEK
     QPDPLHQIIL HFSRNALTER SKLEDDPLYT SYSSMMAKSC QSGEDEEEEE DKEKTFEEKE
     MEKQKTLYQQ ARLHERGAAE MVLQMISASK GEMSPMVVET LKLGIAILNG GNAGVQQKML
     DYLKEKKDAG FFQSLSGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGTLIV RERGEKVLQN
     DEFTRDLFRF LQLLCEGHNS DFQNFLRTQM GNTTTINVII STVDYLLRLQ ESISDFYWYY
     SGKDIIDESG QHNFSKALAV TKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD AVVGFLHVFA
     NMQMKLSQDS SQIELLKELL DLLQDMVVML LSLLEGNVVN GTIGKQMVDT LVESSTNVEM
     ILKFFDMFLK LKDLTSSDTF KEYDPDGKGI ISKKEFQKAM EGQKQYTQSE IDFLLLCAEA
     DENDMFNYID FVDRFHEPAK DIGFNVAVLL TNLSEHMPND SRLKCLLDPA GSVLNYFEPY
     LGRIEIMGGA KKIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE QEKMELFVNF
     CEDTIFEMQL ASQISESDSA ERPDEEEEED EDSSYVLEIE GEEEDDKSFE SASAFAMACA
     SVKRNIANFL KKATLKNLRK QYRKVKKMTV KELVKVFFSF FWMLFVGLFR LFFTILGGIF
     QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDA LDAERAEVTE PGVPPELIHF
     VKGEKGDTDI MSDLFGLHPK KEGGLKHGPE VGLGDLSEII GKDEPPTLES TVRKKRKAQA
     AEMKAAHEAE GKVEPEKTDL EDGEKEDTAK EEEQAEALWA DVTKKKKRRR GQKVEKPEAF
     MANFFKGLEI YQTKLLHYLA RNFYNLRFLA LFVAFAINFI LLFYKVTEEP AEEETEDVAN
     LWNSFTDEEE EEAMVFFVLQ ESTGYMAPAL RALAIIHTVI SLVCVVGYYC LKVPLVVFKR
     EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG
     AERIAELLGL DKNALDFSPV EESKAEAASL VSWLSSIDMK YHVWKLGVVF TDNSFLYLAW
     YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV
     AFNFFRKFYN KSEDDDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI
     VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG
     FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED
     QLG
//
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