ID M3YAQ5_MUSPF Unreviewed; 857 AA.
AC M3YAQ5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Semaphorin 4D {ECO:0000313|Ensembl:ENSMPUP00000008412.1};
DE SubName: Full=Semaphorin-4D isoform X2 {ECO:0000313|RefSeq:XP_012904586.1};
GN Name=SEMA4D {ECO:0000313|Ensembl:ENSMPUP00000008412.1,
GN ECO:0000313|RefSeq:XP_012904586.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008412.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000008412.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_012904586.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_012904586.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AEYP01095461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012904586.1; XM_013049132.2.
DR STRING; 9669.ENSMPUP00000008412; -.
DR Ensembl; ENSMPUT00000008547.1; ENSMPUP00000008412.1; ENSMPUG00000008476.1.
DR GeneID; 101674605; -.
DR KEGG; mpuf:101674605; -.
DR CTD; 10507; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159594; -.
DR HOGENOM; CLU_009051_4_0_1; -.
DR OMA; PCLKFRS; -.
DR OrthoDB; 5342713at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002116; C:semaphorin receptor complex; IEA:Ensembl.
DR GO; GO:0048018; F:receptor ligand activity; IEA:Ensembl.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0061430; P:bone trabecula morphogenesis; IEA:Ensembl.
DR GO; GO:0070486; P:leukocyte aggregation; IEA:Ensembl.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:Ensembl.
DR GO; GO:1905704; P:positive regulation of inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..857
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041199591"
FT TRANSMEM 730..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..498
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 552..634
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 647..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 94999 MW; 51CC33D855F2AD1C CRC64;
MCAPVGGLLA ALAMVLGMAV AFAPKPRITW EHREVHLEKF HEPGIFNYSV LLLSEDKTTL
YVGAREAVFA LSAHNVSEKQ HEAYWKVSED KKAKCAEKGK SRQTECLNYI RVLQPLGPGA
LYVCGTNAFQ PACDHLDLTS FRFLGRREDG KGRCPFDPAQ SYTSVMVDGE LYSGTSYNFL
GSEPIISRNS SHSPLRTEYA IPWLNEPSFV FADVMRERPD GLDSGDDRVY FFFTEVSVEY
EFVFKLMIPR VARVCKGDQG GLRTLQKKWT SFLKARLICS RPDSNLVFNV LQDVFVLRAE
GLKEPVIYGV FTPQLNNVGL SAVCAYHLSA AEEVFSRGKY MQSTTVEQSH TKWVRYNGAV
PTPRPGACIT REARAANLSS SLSLPDKTLQ FVKDHPLMDS SVTPIDNRPR LIRSDVNYTQ
VVVDRTWALD GTPYDVMFVG TDQGTLHKAV SLENEAHIIE ETRLFQDLEP VQTLLLNSQK
GRKFVYAGSS SGVVQAPVAF CEKHATCEDC VLARDPYCAW SPASQACVAL HLPDSPSRDL
IQRMSGDTAG CPNKTKESFR QHFFKHGGTA ELKCSPKSNL ARVVWTFQNN ELKAEGPKYS
LVGRKDLLVF NLSEGDSGVY RCLLEERLRN RTVLHVAARH VLEVRVPPRT PAAPTTPAEG
DRTPLRVSAE PTPGPPAQTP VVLGPALGAM APPPSPTPSS TPCKPKTVVN TVPQVHSEKT
VYLKSSDNRL LMVLFLLCFV LCLGLLSYNC YKGYLPGQCL KFRSAVLLAK KQPAADFSEF
EQSVKETLVE QGSFSQQNGA QPRPALDTGY ETEQDTTASR APTDREDSQR LDDLPGRDRP
FDVKCELKYA DSDADVD
//
