UniProt: M3YBV7

Database: UniProt
Entry: M3YBV7_MUSPF

LinkDB:  M3YBV7_MUSPF 
Original site:  M3YBV7_MUSPF

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Ontology (64)   
   GO (64)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (9)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (81)   

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ID   M3YBV7_MUSPF            Unreviewed;       400 AA.
AC   M3YBV7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Lymphoid enhancer binding factor 1 {ECO:0000313|Ensembl:ENSMPUP00000008814.1};
DE   SubName: Full=Lymphoid enhancer-binding factor 1 isoform X2 {ECO:0000313|RefSeq:XP_004748161.1};
GN   Name=LEF1 {ECO:0000313|Ensembl:ENSMPUP00000008814.1,
GN   ECO:0000313|RefSeq:XP_004748161.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008814.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000008814.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004748161.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004748161.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family.
CC       {ECO:0000256|ARBA:ARBA00006569}.
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DR   EMBL; AEYP01024048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01024049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01024050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004748161.1; XM_004748104.3.
DR   STRING; 9669.ENSMPUP00000008814; -.
DR   Ensembl; ENSMPUT00000008958.1; ENSMPUP00000008814.1; ENSMPUG00000008884.1.
DR   GeneID; 101689480; -.
DR   CTD; 51176; -.
DR   eggNOG; KOG3248; Eukaryota.
DR   GeneTree; ENSGT00940000159660; -.
DR   HOGENOM; CLU_013229_5_0_1; -.
DR   OMA; NFSTCKA; -.
DR   OrthoDB; 5351131at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR   GO; GO:0070016; F:armadillo repeat domain binding; IEA:Ensembl.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR   GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0008301; F:DNA binding, bending; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0045295; F:gamma-catenin binding; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR   GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR   GO; GO:0060033; P:anatomical structure regression; IEA:Ensembl.
DR   GO; GO:1902262; P:apoptotic process involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR   GO; GO:0060710; P:chorio-allantoic fusion; IEA:Ensembl.
DR   GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR   GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR   GO; GO:0021873; P:forebrain neuroblast division; IEA:Ensembl.
DR   GO; GO:0021861; P:forebrain radial glial cell differentiation; IEA:Ensembl.
DR   GO; GO:0021943; P:formation of radial glial scaffolds; IEA:Ensembl.
DR   GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
DR   GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow cell; IEA:Ensembl.
DR   GO; GO:0032696; P:negative regulation of interleukin-13 production; IEA:Ensembl.
DR   GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl.
DR   GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
DR   GO; GO:0045843; P:negative regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR   GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl.
DR   GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
DR   GO; GO:1902732; P:positive regulation of chondrocyte proliferation; IEA:Ensembl.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Ensembl.
DR   GO; GO:1901331; P:positive regulation of odontoblast differentiation; IEA:Ensembl.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
DR   GO; GO:0062009; P:secondary palate development; IEA:Ensembl.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR   GO; GO:0033153; P:T cell receptor V(D)J recombination; IEA:Ensembl.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR   GO; GO:0043586; P:tongue development; IEA:Ensembl.
DR   GO; GO:0061153; P:trachea gland development; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd21996; HMG-box_TCF7-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   PANTHER; PTHR10373:SF11; LYMPHOID ENHANCER-BINDING FACTOR 1; 1.
DR   PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          300..368
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        300..368
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  44280 MW;  CA9AAF3EF0804BF9 CRC64;
     MPQLSGAGGG GGGGDPELCA TDEMIPFKDE GDPQKEKIFA EISHPEEEGD LADIKSSLVN
     ESEIIPASNG HEVARQAQTS QESYHDKARE HPDDGKHPDG GLYNKGPSYS SYSGYIMMPN
     MNNDPYMSNG SLSPPIARTS NKVPVVQPSH AVHPLTPLIT YSDEHFSPGS HPSHLPSDVN
     SKQGMSRHPP APEIPTFYPL SPGGVGQITP PLGWQGQPVY PITGGFRQPY PSSLSVDTSM
     SRFSHHMIPG PPGPHTTGIP HPAIVTPQVK QEHPHTDSDL MHVKPQHEQR KEQEPKRPHI
     KKPLNAFMLY MKEMRANVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH
     MQLYPGWSAR DNYGKKKKRK REKLQESTSG TGPRMTAAYI
//

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