ID M3YCA2_MUSPF Unreviewed; 404 AA.
AC M3YCA2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Sex hormone-binding globulin {ECO:0000256|ARBA:ARBA00040510};
GN Name=SHBG {ECO:0000313|Ensembl:ENSMPUP00000008959.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008959.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000008959.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an androgen transport protein, but may also be
CC involved in receptor mediated processes. Each dimer binds one molecule
CC of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
CC 17-beta-estradiol. Regulates the plasma metabolic clearance rate of
CC steroid hormones by controlling their plasma concentration.
CC {ECO:0000256|ARBA:ARBA00037620}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; AEYP01050882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004760321.1; XM_004760264.2.
DR AlphaFoldDB; M3YCA2; -.
DR STRING; 9669.ENSMPUP00000008959; -.
DR Ensembl; ENSMPUT00000009106.1; ENSMPUP00000008959.1; ENSMPUG00000009031.1.
DR GeneID; 101679796; -.
DR KEGG; mpuf:101679796; -.
DR CTD; 6462; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT00940000154035; -.
DR HOGENOM; CLU_063172_0_0_1; -.
DR InParanoid; M3YCA2; -.
DR OMA; FPLMQIS; -.
DR OrthoDB; 5316510at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24040:SF3; SEX HORMONE-BINDING GLOBULIN; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..404
FT /note="Sex hormone-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004045015"
FT DOMAIN 46..219
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
SQ SEQUENCE 404 AA; 43617 MW; 2B2BD8BB88EE3F1F CRC64;
MEGRGPLATS PGWLSLLLLL LPPPGHQGGA LRHGLSAQRI QDPPAVHLSS GSGQEPITIM
TFDFTKIRKS FSSFELQTWD PEGVIFYGDT NPEDDWFVLA LRDGRPEIQL HNQLTQVTVS
AGPRLDDGRW HQVEVRVLED SLLLSVDGEE VLRLRQVSES LASKPQPIVR IALGGLLFPA
SSLRLPLVPA LDGCLRRGTW LDPQAQTSGS VPMRSLKSCA LQSQPGSFFP PGTHAEFNLQ
DIPQPHAEPW AFSLDVGLQQ AAGSGHLLAL GTPENPSQLS LHLQDQKVVV SSGTGPDLDL
PLVLGLPLQL KLAASGVVLN QGSKKEILAL PALDLASLLK LWVWPQGRLF LGALPGETSS
ASFCLNGLWA QGQKLDMDRA LSRSEDIWTH SCPQGPNNGT DTTH
//
