ID M3YDB0_MUSPF Unreviewed; 462 AA.
AC M3YDB0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSMPUP00000009317.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009317.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000009317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR EMBL; AEYP01093908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01093909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01093910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012904312.1; XM_013048858.1.
DR AlphaFoldDB; M3YDB0; -.
DR STRING; 9669.ENSMPUP00000009317; -.
DR Ensembl; ENSMPUT00000009471.1; ENSMPUP00000009317.1; ENSMPUG00000009392.1.
DR KEGG; mpuf:101689506; -.
DR eggNOG; KOG2502; Eukaryota.
DR GeneTree; ENSGT00940000158155; -.
DR HOGENOM; CLU_028236_1_1_1; -.
DR InParanoid; M3YDB0; -.
DR OMA; FPTYFMH; -.
DR OrthoDB; 603296at2759; -.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0120160; F:intraciliary transport particle A binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0060434; P:bronchus morphogenesis; IEA:Ensembl.
DR GO; GO:0021953; P:central nervous system neuron differentiation; IEA:Ensembl.
DR GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0061548; P:ganglion development; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 30..82
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 84..193
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 214..457
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 37..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 52070 MW; 9C830F2A1554E6E3 CRC64;
MEASRCRLGP RGDSAFEDET MKLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARLRRS
KPRGSEEQTP LVEPHTPQND VILHGIDGPA AFLKPDAQDL ETKLHVLSVG SSATEEDTEE
SVDGESTLET VSKPDLQEIL QKHGISGSLN FDEEETDGEE EGNKLCHSPY SEAERPTSAS
SQKSTTDTGA SGTAAQQMDN QLGEVENLED FAYSPAPRGI TVKCRITRDK KGIDRGLFPT
YYMHLEKDEN RKIFLLAGRK RKKSKTSNYL ISTDPTDLSR EGESYIGKLR SNLMGTKFTV
YDHGVSPTKA QGLVEKTYIR QELAAICYET NVLGFKGPRK MSVIVPGMNM NHERIPFRPR
NDHESLLSKW QNKTMENLIE LHNKAPVWND DTQSYVLNFH GRVTQASVKN FQIVHENDPD
YIVMQFGRVA DDVFTLDYNY PLCALQAFAI GLSSFDSKLA CE
//
