ID M3YE78_MUSPF Unreviewed; 657 AA.
AC M3YE78;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN Name=SLC20A1 {ECO:0000313|Ensembl:ENSMPUP00000009635.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009635.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000009635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00035083};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|ARBA:ARBA00009916,
CC ECO:0000256|RuleBase:RU363058}.
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DR EMBL; AEYP01076485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01076486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01076487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01076488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01076489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01076490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YE78; -.
DR STRING; 9669.ENSMPUP00000009635; -.
DR Ensembl; ENSMPUT00000009791.1; ENSMPUP00000009635.1; ENSMPUG00000009711.1.
DR eggNOG; KOG2493; Eukaryota.
DR GeneTree; ENSGT00390000014879; -.
DR HOGENOM; CLU_015355_3_1_1; -.
DR InParanoid; M3YE78; -.
DR OMA; MSGILFY; -.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:Ensembl.
DR GO; GO:0031214; P:biomineral tissue development; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF46; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 1; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|ARBA:ARBA00022592,
KW ECO:0000256|RuleBase:RU363058}; Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 66..85
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 105..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 566..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT REGION 269..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 71425 MW; D67A93628B9F9504 CRC64;
MASTVTTLTT STIAATAASG PLVDYLWMLI LGFIIAFVLA FSVGANDVAN SFGTAVGSGV
VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN ATQQLLMAGS VSAMFGSAVW
QLVASFLKLP ISGTHCIVGA TIGFSLVAKG QEGVKWSELI KIVMSWFISP LLSGIMSGIL
FFLVRAFILR KADPVPNGLR ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV
GCAVFCALIV WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSLSDIETRN
PIAEVGSATV PLRAVVEERT VSFKLGDLEE APEQERLPSV DLKEETSIDG TMNGAVQLPN
GNLVQFNQAV SNQINSSGHY QYHTVHKDSG LYKELLHKLH LAKVGDCMGD SGDKPLRRNN
SYTSYTMAIC GMPLDSFRAK EGEQKGEEME KLTWPNADSK KRIRMDSYTS YCNAVSDIHS
ASEMDMSVKA EMGLGERKGS SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS
NAIGPLVALY LVYDTRDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP
SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL FRNIFMA
//
