ID M3YG17_MUSPF Unreviewed; 4588 AA.
AC M3YG17;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=FAT atypical cadherin 1 {ECO:0000313|Ensembl:ENSMPUP00000010274.1};
GN Name=FAT1 {ECO:0000313|Ensembl:ENSMPUP00000010274.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010274.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AEYP01046245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01046246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004758360.1; XM_004758303.2.
DR STRING; 9669.ENSMPUP00000010274; -.
DR Ensembl; ENSMPUT00000010438.1; ENSMPUP00000010274.1; ENSMPUG00000010348.1.
DR KEGG; mpuf:101690747; -.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000157733; -.
DR HOGENOM; CLU_000042_2_0_1; -.
DR InParanoid; M3YG17; -.
DR OMA; YSSLYYE; -.
DR OrthoDB; 2961370at2759; -.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 34.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 14.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..4588
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004045200"
FT TRANSMEM 4182..4202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..149
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 150..257
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 368..463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 464..569
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 577..671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 718..822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 823..927
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 928..1034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1043..1139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1140..1245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1246..1363
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1359..1456
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1457..1562
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1563..1667
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1668..1765
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1766..1879
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1880..1979
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1980..2081
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2082..2182
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2183..2283
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2284..2390
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2391..2492
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2493..2596
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2597..2703
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2704..2809
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2810..2918
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2919..3023
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3024..3125
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3126..3230
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3231..3335
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3336..3440
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3441..3545
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3561..3655
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3790..3827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3829..4009
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4013..4050
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4052..4088
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4089..4125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4127..4163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4303..4327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4344..4376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4459..4479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4498..4531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4564..4588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4359..4376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3799..3816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4040..4049
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4078..4087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4115..4124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4153..4162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4588 AA; 506786 MW; 2876FF407265CF6C CRC64;
MGRPLVLLPL LLLLLQHFED GDGSQTFAQM PLQFTHFQYN VTVHENSAAK TYVGHPVKMG
IYLTNPSWEL RYKIVSGDNE NLFKAEEYIL GDFCFLRIRT KGGNTAILNR EVKDHYTLIV
KAVEKNTNAE ARAKVRVQVL DTNDLRPLFS PTSYSVSLPE NTAIRTSIAR VSATDADIGT
NGEFYYSFKD RTDMFAIHPT SGVVVLTGRL DYAETRLYEM EILAVDRGMK LYGSSGISSM
AKLTVHVEQA NGCAPVITAV TLSPSELDKD PTYAIVTVED CDQGPNGEIA SLSIVAGDLL
QQFRTVRSSP GSKEYKVKAV GAIDWDSHPF GYNLTLQAKD KGTPPQFSSV KVIRVTSPQF
KAGPVKFEKD VYRAEISEFA PSNTPVVMVK VTPSYSHLKY VFKSTPGKAK FSLNHNTGLI
SILEPIKRQQ ASHFELEVTT SDRRASTRVL VKVLSANSNP PEFTQTAYKA SFDENVPIGT
TVLSVSAVDP DEGENGYVTY SIANLNHVPF IINHFTGAVS TSEDLDYELM PRVYTLRIRA
SDWGLPYRRE VEVLATVTLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ
LVQYQIEAGN ELDLFSLNPN SGVLSLKQSL LDGIGTRVSF QSLRITATDG ENFATPLYIN
LTVAARRKPV HLQCEETGVA KMLAEKLLQA NKLHSQGEVE DIFFDSHSVN VHAPQFRSTL
PTGIEVKENH PVGSNVIFMN ATDLDTGFNG KLVYAISGGN EDSCFIIDME TGMLKILSPL
DRETTDKYTL NITVSDLGIP QKAAWRLLDI RVLDANDNPP EFLQESYFVE VSEDRELNSE
IIQVEATDKD LGPNGHVTYS ILTDTDKFSI DSMTGVVKIV YPLDREVQHV HYLKIEARDQ
AREEPQLLST VLLKVSLEDV NDNPPRFIPP NYRVKVREDL PEGTIIMWLE AYDPDLGQSS
QVRYSLLDHG EGHFDVDKLS GAVRIVHHLD FEKKQVYNLT MRAKDKGKPV SLSSTCYVEV
EVIDVNENLH PPVFSSFVEK GVVKEDVPIG SSILTVSAHD EDTGRDGEIR YSIRDGSGVG
VFKIDEETGV IETSERLDRE STSHYWLTVY AADRGVVPLS SFIEIYIEVE DVNDNAPQTS
EPVYYPEVIE NSPKDVSVVQ IEAFDPDSTS NDKLMYKITS GNPQGFFSIH PKTGLITTTS
RKLDREQQDE HILEVTVTDN GIPPKSTIAR VIVKILDEND NKPQFLQKFY KIRLPERERP
ERERNAKREP IYRVIATDKD EGPNAEISYS IEDGNEHGKF FIEPKTGVVS SKKFSGAGEY
DILSIKAVDN GRPQKSSTTR LHIEWISKPK PSVEPISFEE PFFSFTVMES DPVAHMIGVI
SVEPPGTPLW FDIIGGNYDS HFDVDKGTGT IIVAKPLDAE QKSSYNLTVE ATDGTTTILT
QVFIKVIDTN DHRPQFSTSK YEVVIPEDTV PETEILQISA MDKDEKNKLI YTLQSSIDPL
SLKKFRLDPA TGSLSTSETL DHEAIHQHIL TVMVRDQDVP VKRNFARIVV NVSDTNDHAP
WFTSSSYEGR VYESAAVGSV VLQVTALDKD KGKNAEVLYS IESGNIGNSF TIDPVLGSIK
TAKELDRNSQ VEYDLMVKAT DQGSPPMSEI TSVHIFVTIA DNASPKFTSK EYSVEISETV
SIGSFVGMVT AHSQSSVVYE IKDGNVADAF DINPHSGSII TQKALDFETL PIYTLIIQGT
NMAGLSTNTT VLVHLQDEND NLPVFMQAEY TGLISESASI NSVVLTDKNI PLVIRATDAD
KESNALLVYH IVEPSVHKYF AIDSSTGAIH TVLSLDYEET STFHFTVQVH DMGTPRLFAA
YAANVTIRVI DINDCPPVFS RSLYEASLLL PTYRGVKVIT VNATDADSSA FSQLMYSITE
GNIGEKFSMD HQTGTITVQN TAQLRSRYEL TVRASDGRFV SFTSVKINVK ESKESQLKFT
RDFYSAVVKE NSTEARTLAV ITAIGNPINE PLFYQILNPD RRFKISRTSG VLSTTGIPFD
REQQEAFDVV VEVTQEQKPS AVAHVVVKVT IEDQNDNAPV FVNLPYYAVV KVDTVVGHVI
RYVTAVDRDS GRNGEVNYYL KEHHEHFQIG ASGEISLKKQ FEPDTLNKEY LITVVAKDGG
NPAFSAEVIV PITVMNKAMP VFEKPFYSAE VPENIQLHSP VVHVQANSPE GLKVLYSISE
GDPFGQFTIN FNTGVLSVVA PLDFESHPAY KLSIRATDSL TGAHAEVFVD IIVEDVNDNA
PVFSQQGYAT ALSEASVIGT SVVQVRATDS DSEPNRGISY HMFGNHSRSH DHFHIDSSTG
LISLVRTLDY EQFQQHRIFV RAVDSGMPPL SSDVIVTVEV TDLNDNPPLF DQQIYEARIS
EHASHGHFVT CVKAYDADNS DVDKLDYSIL SGNDQKNFVM DSETGIITLS NLRRHTLKPF
YSLNISVSDG VFRGSAQVHI TVIGGNLHSP VFLQSEYEVE LAENAPVHTL VIEVKATDGD
SGIYGHITYH IVNDFAKDRF YTNERGQIFT LEKLDRETPA EKVIAVRLMA KDAGGKVAFC
TVNVILTDDN DNAPQFRATR YEVDIGSSAP KGTSVIKVLA SDADEGSNAD VTYAIEADSE
SVKENLEINK LSGVITTKES LIGLENEFFT FFVRAVDSGS PSRESVVPVY VKILPPEIQL
PKFSEPFYTY TVSEDMPIGT EIDLIRAEHS GTILYSLVKG NTPESNRDEF FVIDRQSGRL
KLEKSLDHET TKWYQFSVLA KCTHEDYEVV ASVDVSIQVK DANDNSPVLE SNPYEAFIVE
NLPGGSRVIQ IRASDLDSGT NGQVMYSLDQ SQSVEVIESF AINVETGWIT TLKELDHEER
GNYQIRVVAS DHGEKVQLSS TAIVDVTVTD VNDSPPRFTA EIYKGTVSED DPPGGVIAIL
STTDADSEEI NRQVTYYITG GDPLGQFAIE NIQNEWKVYV KKPLDREKRD NYLLTITATD
GTFSSKAIVE VKVLDANDNS PVCEKTLYSD TIPEDAFPGK LILQVSATDA DIRSNADMTY
TLFGPGAEKF KLNPDTGELK TLAPLDREEQ AIYNLLVKAT DGGGRFCQAN LVLTLEDVND
NAPEFSADLY AITVFENTEP GTLLTRVQAT DADAGLNQKI SYSLIDSADG QFSINELSGI
IQLEKPLDRE QQAVYTLTLK ATDQGLPRRL TATSTVVVSV LDINDNPPVF EYREYGATVS
EDILIGTEVL QVYAASRDIE ANAEITYSII SGNEHGKFSI DSKTGAIFII ENLDYESSHE
YYLTVEATDG GTPSLSDVAT VNINVTDIND NSPVFSQDTY TAVISEDALL EQSVITVMAD
DTDGPSNSHI RYSIIDGNQG SPFTIDPTRG EVKVTKLLDR ETISGYTLTV QASDNGSPPR
VNTTTVNIDV SDVNDNAPVF SRENYSVIIQ ENKPVGFSVL QLVVTDRDSS HNGPPFFFTV
VSGNEDGAFE VNQQGVLLTS AAVKRKEKDH YLLHVKVADN GKPPLSSLTY VDIRVIEESV
YPPAILPLEI FITAFGEEYS GGVIGKIHAT DQDVYDTLTY SLDPQMDKLF SVSSTGGKLI
AHKKLDVGQY LLNVSVTDGR FTTVADITVH IRQVTQEMLN HSITLRFANL TPEEFVGDYW
RNFQRALRNI LGVRRNDVQM VSLQPSEPPP HLDVLLFVEN SGSTPISTKQ LLHKINSSVT
DIEEIIGVRI LDVFQKLCAG LDCPWKFCDE KVTMDENVMS TYSTARLSFV TPRHHRTAVC
LCTEGKCPLV HRGCEDSPCP EGSECVPDPG DNRYSCVCPG GKFGPCPGSS SVTFTGNSFV
KYRLMENENR LEMKLTMRLR TYSAHAVVMY ARGTDYSILE IHNGRLQYKF DCGSGPGIVS
VQSIQVNDGL WHAVSLEVNG NYARLVLDQV HTASGTAPGT LKTLNLDNHV FFGGHIRQQG
TRHGRSPQVG NGFRGCMDSI YLNGQELPLN NKPRSYAHIE EWVDVSPGCL LTATEDCSSN
PCQNGGICHP SPAGGYYCKC SALYVGASCE LSVNPCSSNP CLYGGTCIVD NGDFVCQCRG
LYTGQRCQLS PYCKDEPCKN GGTCFDSLDG AVCQCDSGFR GERCQSDVDE CAASPCRNGA
LCENTHGSYH CNCSREYRGR HCEDATPNQY VSTPWNIGLA EGIGILVFVT GIFLLVGLFV
LCRKIVSRKK KHQAEPEDKH LGPSAAFLQR PYFDAKLNKN IYSDIPPQVP VRPISYTPSI
PSDSRNNLDR NSFEGSAIPE HPEFSTFNPE AVHGHRKAVA VCSVAPNLPP PPPSNSPSDS
DSIQKPSWDF DYDTKVVDLD PCLSKKPLEE KPSHPYSARE SLSEVQSLSS FQSESCDDNG
YHWDTSDWMP SVPLPDIQEF PNYEVIDEQT PLYSADPNAI DTDYYPGGYD IESDFPPPPE
DFPAPDELPP LPPEFSDQFE SIHPPRDMPA AGSLGSSSRN RQRFHLNQYL PNFYPVDMSE
PQKPGAGENS PCREPYAPFP PGYPRNFEAP PAETMPLSVY ASTASCSDVS ACCDVESEVM
MSDYESGEDG HFEEVTVPPL DAQQHTQV
//
