ID M3YHR9_MUSPF Unreviewed; 566 AA.
AC M3YHR9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=F-box and WD repeat domain containing 5 {ECO:0000313|Ensembl:ENSMPUP00000010876.1};
DE SubName: Full=F-box/WD repeat-containing protein 5 isoform X1 {ECO:0000313|RefSeq:XP_012913947.1, ECO:0000313|RefSeq:XP_012913949.1};
GN Name=FBXW5 {ECO:0000313|Ensembl:ENSMPUP00000010876.1,
GN ECO:0000313|RefSeq:XP_012913947.1, ECO:0000313|RefSeq:XP_012913949.1,
GN ECO:0000313|RefSeq:XP_044938692.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010876.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010876.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_012913947.1, ECO:0000313|RefSeq:XP_012913949.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_012913947.1,
RC ECO:0000313|RefSeq:XP_012913949.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01042254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012913947.1; XM_013058493.2.
DR RefSeq; XP_012913948.1; XM_013058494.1.
DR RefSeq; XP_012913949.1; XM_013058495.2.
DR RefSeq; XP_044938692.1; XM_045082757.1.
DR STRING; 9669.ENSMPUP00000010876; -.
DR Ensembl; ENSMPUT00000011058.1; ENSMPUP00000010876.1; ENSMPUG00000010965.1.
DR GeneID; 101689920; -.
DR KEGG; mpuf:101689920; -.
DR CTD; 54461; -.
DR eggNOG; ENOG502QTGQ; Eukaryota.
DR GeneTree; ENSGT00730000111276; -.
DR HOGENOM; CLU_021121_0_0_1; -.
DR OMA; PIMSQLY; -.
DR OrthoDB; 591612at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:0007088; P:regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd22132; F-box_FBXW5; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR042508; FBXW5.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR20995; F-BOX/WD REPEAT-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR20995:SF17; F-BOX_WD REPEAT-CONTAINING PROTEIN 5; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 9..49
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 88..120
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 506..538
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 278..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 63622 MW; F18AA6B4A123DF22 CRC64;
MDEGGTPLLP DSLIYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV
PRHPAATSWY EEFRRLYDTV PCVEVQTLRE HADQVLHLSF SHSGYQFASC SKDCTVKIWN
NDLTISLLHS ADMRPYNWSY TQFSQFNQDD SLLLASGVFL GPHNSSSGEI AVISLDNFAL
LSRVRNKPYD VFGCWLTETS LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK
IQNLNASTIR TVMVADCSRF DSPDLLLDAG ASPSRVFDLG SDSEDEAGGP GPGPAPARTK
EGLRRFLDGL LDGRAQPQLS EHALETKVAE LLAQGRTKPP EQGMADAHKL LIFTTGCLTY
SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID VHGHIIGMGL SPDNRYLYVN
SRAWPSGSVV ADPMQPPPIA EEIDLLVFDL KTMREVKRAL RAHRAYTPND ECFFIFLDVS
RDFVASGAED RHGYIWDRHY NICLAKLRHQ DVVNSVVFSP REQELLLTAS DDATIKAWRS
PRTVRIHQAP RPRPYPFISW FGSQRR
//
