ID   M3YJN2_MUSPF            Unreviewed;       523 AA.
AC   M3YJN2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Glycerate kinase {ECO:0000256|ARBA:ARBA00020720};
DE            EC=2.7.1.31 {ECO:0000256|ARBA:ARBA00012101};
GN   Name=GLYCTK {ECO:0000313|Ensembl:ENSMPUP00000011539.1,
GN   ECO:0000313|RefSeq:XP_004780107.1, ECO:0000313|RefSeq:XP_044935192.1,
GN   ECO:0000313|RefSeq:XP_044935198.1, ECO:0000313|RefSeq:XP_044935201.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011539.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000011539.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004780107.1, ECO:0000313|RefSeq:XP_044935192.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004780107.1,
RC   ECO:0000313|RefSeq:XP_044935192.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+);
CC         Xref=Rhea:RHEA:23516, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216;
CC         EC=2.7.1.31; Evidence={ECO:0000256|ARBA:ARBA00000694};
CC   -!- SIMILARITY: Belongs to the glycerate kinase type-2 family.
CC       {ECO:0000256|ARBA:ARBA00005393}.
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DR   EMBL; AEYP01099203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004780107.1; XM_004780050.3.
DR   RefSeq; XP_044935192.1; XM_045079257.1.
DR   RefSeq; XP_044935198.1; XM_045079263.1.
DR   RefSeq; XP_044935201.1; XM_045079266.1.
DR   STRING; 9669.ENSMPUP00000011539; -.
DR   Ensembl; ENSMPUT00000011729.1; ENSMPUP00000011539.1; ENSMPUG00000011631.1.
DR   GeneID; 101673297; -.
DR   KEGG; mpuf:101673297; -.
DR   CTD; 132158; -.
DR   eggNOG; KOG3935; Eukaryota.
DR   GeneTree; ENSGT00390000014365; -.
DR   HOGENOM; CLU_032279_0_0_1; -.
DR   OMA; GKAAWRM; -.
DR   OrthoDB; 5404098at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0008887; F:glycerate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10180; Glycerate kinase, MOFRL-like N-terminal domain; 1.
DR   Gene3D; 3.40.1480.10; MOFRL domain; 1.
DR   InterPro; IPR037035; GK-like_C_sf.
DR   InterPro; IPR038614; GK_N_sf.
DR   InterPro; IPR007835; MOFRL.
DR   InterPro; IPR025286; MOFRL_assoc_dom.
DR   InterPro; IPR039760; MOFRL_protein.
DR   PANTHER; PTHR12227; GLYCERATE KINASE; 1.
DR   PANTHER; PTHR12227:SF0; GLYCERATE KINASE; 1.
DR   Pfam; PF13660; DUF4147; 1.
DR   Pfam; PF05161; MOFRL; 1.
DR   SUPFAM; SSF82544; GckA/TtuD-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|RefSeq:XP_004780107.1,
KW   ECO:0000313|RefSeq:XP_044935192.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transferase {ECO:0000313|RefSeq:XP_004780107.1,
KW   ECO:0000313|RefSeq:XP_044935192.1}.
FT   DOMAIN          38..288
FT                   /note="MOFRL-associated"
FT                   /evidence="ECO:0000259|Pfam:PF13660"
FT   DOMAIN          402..514
FT                   /note="MOFRL"
FT                   /evidence="ECO:0000259|Pfam:PF05161"
SQ   SEQUENCE   523 AA;  54758 MW;  F9607D610AECFA4E CRC64;
     MAVVLQVLPC VARALLRPLL MGSPVVRLAS GMALAEQAQQ LFESTVGAVL PGPMLQRALC
     LDPSSGLLKV RDRSFQLRQN LYLVGFGKAV LGMAAAAEEL LGQHLVQGVI SVPKGIRAAM
     EHAGKQEMLL KPHSRVQVFE GAEDNLPDRD ALRAAVAIRQ LAEGLTADDL LLVLISGGGS
     ALLPAPIPPV TLEEKQTLTK LLAARGANIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI
     LSDVVGDPVE VIASGPTVAS VHSVQDCLHI LNHYGLRAAL PRSVKTVLAQ SDSDPHGPHS
     CGHVLNVIIG SNALALAEAQ RQAEALGYRA VVLSAAIQGD VKSVARFYGL LTRVAGAHLT
     PPVTRASVEE EAQLWELAAE LHLPDLQLKE ALEAVVEAGG PVCLLAGGEP TVQLQGSGKG
     GRNQELALRV GAELGQRPLG PLEVLFLSGG TDGQDGPTEA AGAWVVPELA SQAAAEGLDV
     AAFLSRNDSH TFFRCFRGGA HLLHTGLTGT NVMDAHLLFL RPR
//