ID M3YJQ9_MUSPF Unreviewed; 919 AA.
AC M3YJQ9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=DDR1 {ECO:0000313|Ensembl:ENSMPUP00000011566.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011566.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AEYP01102818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012906003.1; XM_013050549.1.
DR RefSeq; XP_012906005.1; XM_013050551.1.
DR RefSeq; XP_012906006.1; XM_013050552.1.
DR RefSeq; XP_012906007.1; XM_013050553.1.
DR RefSeq; XP_012906008.1; XM_013050554.1.
DR RefSeq; XP_012906009.1; XM_013050555.1.
DR AlphaFoldDB; M3YJQ9; -.
DR STRING; 9669.ENSMPUP00000011566; -.
DR Ensembl; ENSMPUT00000011757.1; ENSMPUP00000011566.1; ENSMPUG00000011659.1.
DR GeneID; 101672046; -.
DR KEGG; mpuf:101672046; -.
DR CTD; 780; -.
DR eggNOG; KOG1094; Eukaryota.
DR GeneTree; ENSGT00940000159733; -.
DR HOGENOM; CLU_008873_2_0_1; -.
DR InParanoid; M3YJQ9; -.
DR OMA; DVQVFSH; -.
DR OrthoDB; 2999496at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0038062; F:protein tyrosine kinase collagen receptor activity; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IEA:Ensembl.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0043583; P:ear development; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1990138; P:neuron projection extension; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
DR GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0010715; P:regulation of extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0014909; P:smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0061302; P:smooth muscle cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd05096; PTKc_DDR1; 1.
DR Gene3D; 2.60.120.1190; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR048525; DDR1-2_DS-like.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF333; EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF21114; DDR1-2_DS-like; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..919
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004044929"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..188
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 616..911
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 476..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..502
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 101491 MW; 1A075026414CF061 CRC64;
MGPGALTSLP LLLLLLLVAT GDADMKGHFD PAKCRYALGM QDRTIPDGDI SASSSWSDST
AARHSRLESS DGDGAWCPAG PVFPKEEEYL QVDLRRLHLV ALVGTQGRHA GGLGKEFSPS
YRLRYSRDGH RWMDWRDRWG QEVILGNEDP GGVVLKDLGP PMVARLVRFY PRADRVMSVC
LRVELYGCLW KDGLLSYTAP VGQTMYLSEA VHLNDSTYDG HTTHAVGGLL YGGLGQLADG
VVGLDDFRKS QELRVWPGYD YVGWSNHSFP AGYVEMEFEF DRLRVFQAMQ VHCNNMHTLG
ARLPGGVECR FKRGPAMAWE GEPVRHALGG SLGDPRARAV SVPLGGRVGR FLQCRFLFAG
PWLLFSEISF ISDVMNDSSP ALGGTFPPAP WWPPGPPPTN FSSLELEPRG QQPVAKAEGS
PTAILIGCLV AIILLLLLII ALMLWRLHWR RLLSKAERRV LEEELTVHLS VPGDTILINN
RPGPLEPPPY QEPRPRGNPP HSAPSVPNSS ALLLSNPAYR LLLATYARPP RGPGPPTPAW
AKPTNTQACS GDYMEPEKPG APLLPPPPQN SVPHYAEADI VTLQGVTGGN TYAVPALPPG
AAGDGPPRVD FPRSQLRFKE KLGEGQFGEV HLCEVENPQD LVSLDFPLNV CKGHPLLVAV
KILRPDATKN ARNDFLKEVK IMSRLKDPNI IRLLGVCVQD DPLCMITDYM ENGDLNQFLS
AHQLEDKVAE GAPRDGEAAP GPTISYPMLL HVVAQIASGM RYLATLNFVH RDLATRNCLV
GENFTIKIAD FGMSRNLYAG DYYRVQGRAV LPIRWMAWEC ILMGKFTTAS DVWAFGVTLW
EVLMLCRAQP FGQLTDEQVI ENAGEFFRDQ GRQVYLSRPP ACPLGLYELM LRCWSREPEQ
RPPFSQLHRF LAEDALNTV
//
