ID M3YJY4_MUSPF Unreviewed; 1082 AA.
AC M3YJY4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Importin 5 {ECO:0000313|Ensembl:ENSMPUP00000011641.1};
GN Name=IPO5 {ECO:0000313|Ensembl:ENSMPUP00000011641.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011641.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011641.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AEYP01019716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YJY4; -.
DR STRING; 9669.ENSMPUP00000011641; -.
DR Ensembl; ENSMPUT00000011833.1; ENSMPUP00000011641.1; ENSMPUG00000011735.1.
DR eggNOG; KOG2171; Eukaryota.
DR GeneTree; ENSGT00940000155502; -.
DR HOGENOM; CLU_003794_0_0_1; -.
DR InParanoid; M3YJY4; -.
DR OMA; PKRFVQE; -.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0006610; P:ribosomal protein import into nucleus; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR040928; Importin_rep_5.
DR InterPro; IPR041389; Importin_rep_6.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF22; IMPORTIN-5; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18816; Importin_rep_5; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 30..84
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1082 AA; 121952 MW; 8DF2D771C4A4F4A3 CRC64;
MGTAVLPDQD PCSTQETYEN IPGQSKITFL LQAIRNTTAA EEARQMAAVL LRRLLSSAFD
EVYPTLPSDV QTAIKSELLM IIQMETQSSM RKKICDIAAE LARNLIDEDG NNQWPEGLKF
LFDSVSSQNM GLREAALHIF WNFPGIFGNQ QQHYLDVIKR MLVQCMQDQE HPSIRTLSAR
ATAAFILANE HNVALFKHFA DLLPGFLQAV NDSCYQNDDS VLKSLVEIAD TVPKYLRPHL
EATLQLSLKL CGDTSLNNMQ RQLALEVIVT LSETAAAMLR KHTNIVAQTI PQMLAMMVDL
EEDEDWANAD ELEDDDFDSN AVAGESALDR MACGLGGKLV LPMIKEHIMQ MLQNPDWKYR
HAGLMALSAI GEGCHQQMEG ILNEIVNFVL LFLQDPHPRV RYAACNAVGQ MATDFAPGFQ
KKFHEKVIAA LLQTMEDQGN QRVQAHAAAA LINFTEDCPK SLLIPYLDNL VKHLHSIMVL
KLQELIQKGT KLVLEQVVTS IASVADTAEE KFVPYYDLFM PSLKHIVENA VQKELRLLRG
KTIECISLIG LAVGKEKFMQ DASDVMQLLL KTQTDFSDME DDDPQISYMI SAWARMCKIL
GKEFQQYLPV VMGPLMKTAS IKPEVALLDT QDMENMSDDD GWEFVNLGDQ QSFGIKTAGL
EEKSTACQML VCYAKELKEG FVEYTEQVVK LMVPLLKFYF HDGVRVAAAE SMPLLLECAR
VRGPEYLTQM WHFMCDALIK AIGTEPDSDV LSEIMHSFAK CIEVMGDGCL NNEHFEELGG
ILKAKLEEHF KNQELRQVKR QDEDYDEQVE ESLQDEDDND VYILTKVSDI LHSIFSSYKE
KVLPWFEQLL PLIVNLICPH RPWPDRQWGL CIFDDVIEHC SPASFKYAEY FLRPMLQYVC
DNSPEVRQAA AYGLGVMAQY GGDNYRPFCT EALPLLVRVI QSADSKTKEN VNATENCISA
VGKIMKFKPD CVNVEEVLPH WLSWLPLHED KEEAVQTFNY LCDLIESNHP IVLGPNNTNL
PKIFSIIAEG EMHEAIKHED PCAKRLANVV RQVQTSGGLW TECIAQLSPE QQAAIQELLN
SA
//
