ID M3YK14_MUSPF Unreviewed; 768 AA.
AC M3YK14;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator like 1 {ECO:0000313|Ensembl:ENSMPUP00000011671.1};
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 isoform X4 {ECO:0000313|RefSeq:XP_004768000.1};
GN Name=RGL1 {ECO:0000313|Ensembl:ENSMPUP00000011671.1,
GN ECO:0000313|RefSeq:XP_004768000.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011671.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011671.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004768000.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004768000.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01068884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01068885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01068886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01068887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01068888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01068889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004768000.1; XM_004767943.3.
DR STRING; 9669.ENSMPUP00000011671; -.
DR Ensembl; ENSMPUT00000011863.1; ENSMPUP00000011671.1; ENSMPUG00000011765.1.
DR GeneID; 101687864; -.
DR CTD; 23179; -.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000156012; -.
DR HOGENOM; CLU_010252_0_1_1; -.
DR OMA; KCNPYYA; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17210; RA_RGL; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030748; RGL1_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 65..196
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 232..501
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 648..735
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 532..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 86578 MW; B912DD4DD05B0306 CRC64;
MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD QLPPGHTVSQ
YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY RGFASTKEVL ELLLDRYGNL
TSPNCEEDGS PSSSESRTVI RNAIASILRA WLDQCAEDFR EPPHFPCLQK LLDYLKRMMP
GSDPERRAQN LLEQFQKQEV ETDNGFPSTI FFSLEEEEEL EVGGPAEFTS FPEDLVAEQL
TYMDAQLFKK VVPHHCLGCI WSRRDKKENK HLAPTIRATI SQFNTLTKCV ASTVLGGKEL
KTQQRAKVIE KWINIAHECR ILKNFSSLRA IISALQSNSI YRLKKTWAAV PKDRMLMFEE
LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT QRRLQLQKDM GVMQGTVPYL
GTFLTDLTML DTALQDYIEG GLINFEKRRR EFEVIAQIKL LQSACNSYCM TPDPKFIQWF
QRQQLLTEEE SYALSCEIEA AADASATSPK PRKSMVKRLS LLFLGSDIIT SSTPTKEQPK
STASGSSGES MDSVSVSSCE SNHSEAEEGS ITPMDTPDEP QKKLSESSSS CSSLHSMDTT
SSGMSSLMNP LSSPPSCNNN PKIHKRSVSV TSITSTVLPP VYNQQNEDTC IIRISVEDNN
GNMYKSIMLT SQDKTPAVIQ RAMLKHNLDS DPAEEYELVQ VISEDKELVI PDSANVFYAM
NSQVNFDFIL RKKNPMEEQV KLRSRTSLTL PRTAKRGCWS NRHSKVTL
//
