ID M3YKF0_MUSPF Unreviewed; 523 AA.
AC M3YKF0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit beta 2 {ECO:0000313|Ensembl:ENSMPUP00000011807.1};
GN Name=CACNB2 {ECO:0000313|Ensembl:ENSMPUP00000011807.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011807.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}.
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DR EMBL; AEYP01043423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012914350.1; XM_013058896.1.
DR AlphaFoldDB; M3YKF0; -.
DR STRING; 9669.ENSMPUP00000011807; -.
DR Ensembl; ENSMPUT00000012000.1; ENSMPUP00000011807.1; ENSMPUG00000011897.1.
DR KEGG; mpuf:101674245; -.
DR eggNOG; KOG3812; Eukaryota.
DR GeneTree; ENSGT00950000182837; -.
DR HOGENOM; CLU_021995_3_0_1; -.
DR InParanoid; M3YKF0; -.
DR OMA; XELFDVI; -.
DR OrthoDB; 2953516at2759; -.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR GO; GO:0098684; C:photoreceptor ribbon synapse; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR GO; GO:0099626; F:voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; IEA:Ensembl.
DR GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0098912; P:membrane depolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR CDD; cd11863; SH3_CACNB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR005444; VDCC_L_b2su.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR PRINTS; PR01628; LCACHANNELB2.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transport {ECO:0000256|ARBA:ARBA00022568};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 143..324
FT /note="Guanylate kinase/L-type calcium channel beta
FT subunit"
FT /evidence="ECO:0000259|SMART:SM00072"
FT REGION 53..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 59052 MW; CB5F80DBAC9BC45E CRC64;
MAISFEAKDF LHVKEKFNND WWIGRLVKEG CEIGFIPSPV KLENMRLQHE QRAKQGKFYS
SKSGGNSSSS LGDIVPSSRK STPPSSAIDI DATGLDAEGN DIQANHRSPK PSANSVTSPH
SKEKRMPFFK KTEHTPPYDV VPSMRPVVLV GPSLKGYEVT DMMQKALFDF LKHRFEGRIS
ITRVTADISL AKRSVLNNPS KHAIIERSNT RSSLAEVQSE IERIFELART LQLVVLDADT
INHPAQLSKT SLAPIIVYVK ISSPKVLQRL IKSRGKSQAK HLNVQMVAAD KLAQCPPELF
DVILDENQLE DACEHLADYL EAYWKATHPP SSHLPNPLLS RTLATSALPS SPTQASNSQG
SQGDQRTERS APARSASQPE EEPCPEPVKK PQHRSSSSAQ HHSHRSGTSR GLSRQETFDS
ETQESRDSAY VEPKEDYSHE HVDHYAPHRD HNHREEPHGS SEHRHRESRH RSRDLDREQD
HNECNKQRSR HKSKDRYCDK DGEGLSKKRN EAGEWNRDVY IRQ
//
