ID M3YKZ3_MUSPF Unreviewed; 370 AA.
AC M3YKZ3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Vascular endothelial growth factor C {ECO:0000313|Ensembl:ENSMPUP00000012000.1};
GN Name=VEGFC {ECO:0000313|Ensembl:ENSMPUP00000012000.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012000.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01086968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YKZ3; -.
DR STRING; 9669.ENSMPUP00000012000; -.
DR Ensembl; ENSMPUT00000012196.1; ENSMPUP00000012000.1; ENSMPUG00000012093.1.
DR eggNOG; ENOG502QVXE; Eukaryota.
DR GeneTree; ENSGT00940000156167; -.
DR HOGENOM; CLU_061712_1_0_1; -.
DR InParanoid; M3YKZ3; -.
DR OMA; ALPQCQA; -.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0043185; F:vascular endothelial growth factor receptor 3 binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0014009; P:glial cell proliferation; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:1901492; P:positive regulation of lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:Ensembl.
DR GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR004153; CXCXC_repeat.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF3; VASCULAR ENDOTHELIAL GROWTH FACTOR C; 1.
DR Pfam; PF03128; CXCXC; 3.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 68..167
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 370 AA; 41881 MW; C1D7785B32271335 CRC64;
AYAGKDLEEQ LRSVSSVDEL MTVLYPEYWK MYKCQLRKGG WQRYKEQPNI NARTEETVKF
AAAHYNAEIL KSIDNEWRKT QCVPREVCID VGKEFGAATN TFFKPPCVSV YRCGGCCNSE
GLQCMNTSTS HLSKTLFEIT VPLSQGPKPV TISFANHTSC RCMSKLDVYR QVHSIIRRSL
PATLPQCQAA NKTCPTNYFW NNHLCRCLAQ QDFIFSSNSG DDSADGFHDI CGPNKELDEE
TCQCVCKGGL QPSSCGPHKE LDRNSCQCVC KNKLLPSSCG ANREFDETTC QCVCRRTCPR
HQPLNPGKCA CECTENSQKC LLKGKKFQHQ TCSCYRRPCA NRPKHCDQGL LFSEEVCRCV
PSYWKRPHMN
//