ID   M3YLB5_MUSPF            Unreviewed;       955 AA.
AC   M3YLB5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=ADAMTS like 2 {ECO:0000313|Ensembl:ENSMPUP00000012122.1};
DE   SubName: Full=ADAMTS-like protein 2 isoform X1 {ECO:0000313|RefSeq:XP_004757067.1, ECO:0000313|RefSeq:XP_044938632.1};
GN   Name=ADAMTSL2 {ECO:0000313|Ensembl:ENSMPUP00000012122.1,
GN   ECO:0000313|RefSeq:XP_004757067.1, ECO:0000313|RefSeq:XP_044938632.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012122.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000012122.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004757067.1, ECO:0000313|RefSeq:XP_044938632.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004757067.1,
RC   ECO:0000313|RefSeq:XP_044938632.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AEYP01042382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004757067.1; XM_004757010.3.
DR   RefSeq; XP_044938632.1; XM_045082697.1.
DR   STRING; 9669.ENSMPUP00000012122; -.
DR   Ensembl; ENSMPUT00000012322.1; ENSMPUP00000012122.1; ENSMPUG00000012219.1.
DR   GeneID; 101691146; -.
DR   KEGG; mpuf:101691146; -.
DR   CTD; 9719; -.
DR   eggNOG; KOG3538; Eukaryota.
DR   GeneTree; ENSGT00940000159447; -.
DR   HOGENOM; CLU_000660_6_1_1; -.
DR   OMA; CGEGHQF; -.
DR   OrthoDB; 2910701at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0050436; F:microfibril binding; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0060481; P:lobar bronchus epithelium development; IEA:Ensembl.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 5.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 7.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR613273-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..955
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041118920"
FT   DOMAIN          916..954
FT                   /note="PLAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50900"
FT   REGION          412..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        59..100
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        63..105
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        74..90
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ   SEQUENCE   955 AA;  104201 MW;  2EB9807988E73DA8 CRC64;
     MDGGRQPSLW VWSLLAGALL AGGMAPTGAT DNSPTSNSLE GGTDATAYWW GEWTKWTACS
     RSCGAGVTSQ ERHCLQQRRT SVLGAGNRTC TGTSKRYQLC RVQDCPPDGR SFREEQCISF
     NSRVYDGRTH QWKPLYPDDY VHISSKPCDL HCTTVDGQRQ LMVPARDGTS CKLTDLRGVC
     VSGKCEPIGC DGVLFSTHTL DKCGVCQGDG SSCTHVTGNY RKGNAHLGYS LVTHIPAGAR
     DIQIVERKKS ADVLALADEA GSYFFNGNFK VDSPKNFNIA GTVVKYRRPM DVYETGIEYI
     VAQGPTNQGL NVMVWNQNGK SPSITFEYTL LQPPHARRLQ PVYYSFSEPA SESAESQELD
     GAALLGFLRH NGSFYGQTSS ERLGLDNRLF GHLGPGIELG LSKGQETNEV CEQAGGGSCE
     GPPRGKGFRD GNATGTALAG DKDDQEVDAR LPSQRLLSAN VISDQLLGAG SDSRELPFNE
     TGNSIFAPGG PRSSAAESLY ADYEENGGGG AYLLNGSYLE LHSDGMTNVS SEAPFPNASA
     SLPTLAGNRT HKARTRPKAR KQGVSPADMY RWKLSSHEPC SATCATGVLS TYAMCVRYDG
     IEVDDSFCDA LTRPEPVQEF CAGRECQPRW ETSSWSECSR TCGEGYQVRI VRCWKMLSPG
     FDSSVYSDLC EAAEAVRPEE RKTCRNPACG PQWEMSEWSE CAAKCGEQSV VTRDIRCSED
     EKLCDPDTRP VGEKDCTGPP CDRQWTVSDW GPCSGSCGHG RMIRHVYCKT GDGRVVPESQ
     CQTETKPLAI HPCGDKNCPA HWLAQDWERC NTTCGRGVKK RLVLCMELAN GKPQTRSGPE
     CGLAKKPPEE STCFERPCFK WYTSPWSECT KTCGVGVRMR DVKCYQGTDI VRGCDPLVKP
     VGRQACDLQP CPTEPPDDSC QDQPGTNCAL AIKVNLCGHW YYSKACCRSC RPPHT
//