ID M3YLT4_MUSPF Unreviewed; 691 AA.
AC M3YLT4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Adhesion G protein-coupled receptor F4 {ECO:0000313|Ensembl:ENSMPUP00000012291.1, ECO:0000313|RefSeq:XP_004739785.1};
GN Name=ADGRF4 {ECO:0000313|Ensembl:ENSMPUP00000012291.1,
GN ECO:0000313|RefSeq:XP_004739785.1, ECO:0000313|RefSeq:XP_004739786.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012291.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004739785.1, ECO:0000313|RefSeq:XP_004739786.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004739785.1,
RC ECO:0000313|RefSeq:XP_004739786.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; AEYP01005989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004739785.1; XM_004739728.3.
DR RefSeq; XP_004739786.1; XM_004739729.3.
DR STRING; 9669.ENSMPUP00000012291; -.
DR Ensembl; ENSMPUT00000012492.1; ENSMPUP00000012291.1; ENSMPUG00000012385.1.
DR GeneID; 101693497; -.
DR KEGG; mpuf:101693497; -.
DR CTD; 221393; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161797; -.
DR HOGENOM; CLU_002753_3_6_1; -.
DR OMA; WFIINSN; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR45813:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR F4; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_004739785.1,
KW ECO:0000313|RefSeq:XP_004739786.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..691
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158601"
FT TRANSMEM 398..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 399..654
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 691 AA; 77095 MW; 0DA60121B6637B31 CRC64;
MKSQATMICC LMFFLGIECS HYKSKVHIKD GDKRQHPEGK LMTGRIQEKC QGPCTMASNC
SQPCAQHFRG EIGFTCHQNK WQKSTETCTS LSVETLFKDF SSASRLSLAA SSVPVHVLDF
RAPEPVESVA QGILRNCPID YACILDVVKS SEATSGNIAF IVELLRNIST DLSDNVTQEK
MKSYSEVANH ILDTAAISNW AFIPDKNTSS DLLQSVNLFA RQLRMHNESE NLADELFIQA
KGLRINHNTS EKKFNFSASM NSTTEGILGM IEIPRQDLWK LSPNASQAIS IAFPTLGAIL
KEVRSQNVSL PRPVNGLVLS VILPEGLKQV LFTFEKINKS RNARAQCVGW HSRKRRWDEN
ACETTLEITN RVKCLCNYTN MVMSFSILMS PKSIDNKVLY YITCIGLSIS ILSLILCLTI
EALVWSRVVV TEISYLRHVC IVNIAVSLLI ANVWFIINSN FHKKAQDSKW CVALTFFSHF
FYLSLFFWMF FKALLIIYGI LVVFRRMMKS RLMAIGFAIG YGCPLVIAGT TVAITVPEKG
YTRPDACWLN WDNTKALLAF AIPALVIVAV NLVVVLVVAV NTQRPSIGSS KSQDLAIIMR
ISKNVAILTP LLGLTWGFGV ATLIEGTSLI FHIIFALLNA FQGFFILLFG TIMDHKIRDA
LKMRMSSLNG RTRVAENASL SPTNGSKLMN R
//
