ID M3YN75_MUSPF Unreviewed; 751 AA.
AC M3YN75;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Zinc finger with KRAB and SCAN domains 7 {ECO:0008006|Google:ProtNLM};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012782.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012782.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR EMBL; AEYP01082825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004774212.1; XM_004774155.2.
DR RefSeq; XP_012902125.1; XM_013046671.1.
DR RefSeq; XP_012902126.1; XM_013046672.1.
DR AlphaFoldDB; M3YN75; -.
DR STRING; 9669.ENSMPUP00000012782; -.
DR Ensembl; ENSMPUT00000012989.1; ENSMPUP00000012782.1; ENSMPUG00000012880.1.
DR GeneID; 101692431; -.
DR KEGG; mpuf:101692431; -.
DR CTD; 55888; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164428; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; M3YN75; -.
DR OMA; ILKGQKF; -.
DR OrthoDB; 3911447at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 13.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF406; ZINC FINGER PROTEIN 684; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 54..136
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 228..301
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 380..407
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 408..435
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 436..463
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 464..491
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 492..519
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 520..547
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 548..575
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 576..603
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 604..631
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 632..659
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 660..687
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 688..715
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 716..743
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 276..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 84147 MW; 255983B1C8E9F1F4 CRC64;
MTTQGRGTLG LLPNGAVLQK HEGRQTMKQE PGSQTWGQGC SLQKNHPPVC EIFRLHFRQL
CYHEMSGPQE ALSRLRELCQ WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE
SGEEAVAVVE DFQRHIGEVS APVQEQKMHL EDMTALGTTE ESLPTSSFSE SSGSGACLEP
PHDPGIHLLR TGHSAQCASQ VPALFQAGKS GDQAAATVLQ MVGPQGSAAY QFLSVDYTER
KWKGPALSQR AVFQSIMPEN YCSVVSMAGE TRMQHSECPA KQEVSKEPGS PGETSGGLCG
IVSEELEAGA ACEGTLEKLE GQPSEEEGSR LENDFFKITH EDKDKSTKDG CDEYNELGKH
PDLSSSAVEC QGVLKGQKFY QCDECGKAFN RSSHLTGHQR IHTGEKPYEC NECGKTFRQT
SQLIVHLRTH TGEKPYECNE CGNTYRHSSH LIQHQRLHNG EKPYKCNECA KAFTQSSQLI
DHQRTHTGEK PYECTECGEA FIRSKSLVRH QVVHTGKKPY RCSECGKAFC SNRNLVDHQR
IHTGEKPYEC NECGKAFSRS KCLIRHQSLH TGQKPYKCSD CGKAFNQNSQ LVDHERIHTG
EKPFECNECG KAFSLSKCLI RHQRLHTGEK PYKCNECGKS FNQNSHLIIH QRIHTGEKPY
ECNECGKVFS YSSSLMVHQR THTGEKPYKC SNCGKAFSDS SQLIVHQRVH TGEKPYECIE
CGKAFSQRST FNHHQRTHIG EKHSGLAHSV S
//
