ID   M3YPM6_MUSPF            Unreviewed;       939 AA.
AC   M3YPM6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=USH1 protein network component harmonin {ECO:0000313|Ensembl:ENSMPUP00000013284.1};
GN   Name=USH1C {ECO:0000313|Ensembl:ENSMPUP00000013284.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013284.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000013284.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
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DR   EMBL; AEYP01030457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3YPM6; -.
DR   STRING; 9669.ENSMPUP00000013284; -.
DR   Ensembl; ENSMPUT00000013496.1; ENSMPUP00000013284.1; ENSMPUG00000013383.1.
DR   eggNOG; KOG3528; Eukaryota.
DR   GeneTree; ENSGT00950000183002; -.
DR   HOGENOM; CLU_019813_0_0_1; -.
DR   InParanoid; M3YPM6; -.
DR   OMA; TISAEMH; -.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0005903; C:brush border; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR   GO; GO:1904970; P:brush border assembly; IEA:Ensembl.
DR   GO; GO:0050957; P:equilibrioception; IEA:Ensembl.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR   GO; GO:1904106; P:protein localization to microvillus; IEA:Ensembl.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0050953; P:sensory perception of light stimulus; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   CDD; cd07353; harmonin_N; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 1.20.1160.20; -; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   InterPro; IPR030237; Harmonin_N.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR23116:SF36; HARMONIN; 1.
DR   PANTHER; PTHR23116; PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF21219; USH1C_N; 1.
DR   PRINTS; PR01217; PRICHEXTENSN.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   PROSITE; PS50106; PDZ; 3.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          86..154
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          210..280
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          751..824
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          586..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          895..939
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          300..376
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          422..477
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        596..615
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..683
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        903..939
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  105635 MW;  AB5D8BE99433FCC0 CRC64;
     KAVIRHYSHH QVDFLIENDA EKDYLYDVLR MYHQTMDVAV LVGDLKLVIN EPSRLPLFDA
     IRPLIPLKHQ VEYDQLTPRR SRKLKEVRLD RLHPEGLGLS VRGGLEFSCG LFISHLIKGG
     QADNVGLQVG DEIVRINGYS ISSCTHEEVI NLIRTKKTVS IKVRHIGLIP VKSSPEEPLK
     WQYVDQFVSE SGGGRSSLAF PGSRENKEKK VFISLVGSRG LGCSISSGPV QKPGIFISNV
     KPGSLSAEVG LETGDQIVEV NGIDFSNLDH KEAVNVLKSS RSLTISIVAG AGRELFLTDR
     ERLEEARQRE LQRQELLMQK RLAMESNKIL QEQQEMERQR KKEIAQKAAE ENERYRKEME
     QIIEDEEKFK KQWEEDWGSK EQLLSPKTIT AEVHPVPLRK PKSFGWFYRY DGKFPTIRKK
     GKDKKKAKYD SLQELRKNKK ELEFEQKLYK EKEEMLEKEK QLKINRLAQE VSETEREDLE
     ESEKIQYWVE RLCQTRLEQI SSADNEISEM TTGPPPPPPS VSPLVPPLRR FAGGLHLHTT
     DLDDIPLDMF YYPPKTPSAL PVMPHPPPST PSPKVPAPPV LPSSGHVCAS SSPWVQRTPP
     PIPIPPPPSV PTQDLTPTRP LPSALEEALG NHPFRAGDTG NPTEDWEAKN HSGKPTSSPV
     PERSFPPTPK TFCPSPQPPR GPGVSTISKP VMVHQEPNFI YRPAVKSEVL PQEMLKRMVV
     YQTAFRQDFR KYEEGFDPYS MFTPEQILGK DVRLLRIKKE GSLDLALEGG VDSPIGKVVV
     SAVYEGGAAE RHGGIVKGDE VMAINGKIVT DYTLAEAEAT LQKAWSQGGD WIDLVVAVCP
     PKEYDDELSA LPSSAAESPH VRKVLEVRAP MPRHGFLLQL EPDDLLLKPR RRNHIHPEKP
     VSSGFTLLNT KPRPSLESQL AGPLETYSQH PRISSSPWP
//