ID M3YQ35_MUSPF Unreviewed; 461 AA.
AC M3YQ35;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Protein-serine O-palmitoleoyltransferase porcupine {ECO:0000256|ARBA:ARBA00040371};
DE EC=2.3.1.250 {ECO:0000256|ARBA:ARBA00038867};
GN Name=PORCN {ECO:0000313|Ensembl:ENSMPUP00000013443.1,
GN ECO:0000313|RefSeq:XP_004755064.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013443.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004755064.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004755064.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt
CC protein]-O-(9Z)-hexadecenoyl-L-serine + CoA; Xref=Rhea:RHEA:45336,
CC Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:85189;
CC EC=2.3.1.250; Evidence={ECO:0000256|ARBA:ARBA00035752};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC Porcupine subfamily. {ECO:0000256|ARBA:ARBA00038269}.
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DR EMBL; AEYP01038455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004755064.1; XM_004755007.3.
DR STRING; 9669.ENSMPUP00000013443; -.
DR Ensembl; ENSMPUT00000013659.1; ENSMPUP00000013443.1; ENSMPUG00000013546.1.
DR GeneID; 101669917; -.
DR KEGG; mpuf:101669917; -.
DR CTD; 64840; -.
DR eggNOG; KOG4312; Eukaryota.
DR GeneTree; ENSGT01030000234564; -.
DR HOGENOM; CLU_048745_0_0_1; -.
DR OMA; AKWLLAY; -.
DR OrthoDB; 2957548at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:1990698; F:palmitoleoyltransferase activity; IEA:Ensembl.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:Ensembl.
DR GO; GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR13906; PORCUPINE; 1.
DR PANTHER; PTHR13906:SF12; PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE; 1.
DR Pfam; PF03062; MBOAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 461 AA; 52401 MW; E6912A44708AB4E2 CRC64;
MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG
FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW
HKMRGAQMIV AMKAVSLGFD LDRGEVGAVP SPMEFMGYLY FVGTIVFGPW ISFHSYLQAV
QGRPLSRQWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LDGDRLLRNK KRKARGTMVR
WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE
VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV
EHVLRKRLAR ILSACVLSKR CPPNCSHRHR LGLGVRVLNL LFGALAIFHL AYLGSLFDVD
VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G
//
