ID M3YQN0_MUSPF Unreviewed; 382 AA.
AC M3YQN0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Growth differentiation factor 7 {ECO:0000313|Ensembl:ENSMPUP00000013639.1};
GN Name=GDF7 {ECO:0000313|Ensembl:ENSMPUP00000013639.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013639.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AEYP01019049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01019050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YQN0; -.
DR STRING; 9669.ENSMPUP00000013639; -.
DR Ensembl; ENSMPUT00000013856.1; ENSMPUP00000013639.1; ENSMPUG00000013742.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160140; -.
DR HOGENOM; CLU_020515_0_0_1; -.
DR InParanoid; M3YQN0; -.
DR OMA; RAPRAFC; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:2001051; P:positive regulation of tendon cell differentiation; IEA:Ensembl.
DR GO; GO:0048608; P:reproductive structure development; IEA:Ensembl.
DR GO; GO:0021509; P:roof plate formation; IEA:Ensembl.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF160; GROWTH_DIFFERENTIATION FACTOR 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 250..382
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 228..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 40695 MW; 8D7C34A8B082AB28 CRC64;
AARPPGPRSS VVPHQFMMSL YRNLAGRAPA GAAAASTSGS GRHGRADTIT GFADQANQDE
SPAETGQSFL FDVSSLPDTD EVVRAELRVL RHESPELGPG GATPPPLLLL LSTCPGAARA
PRLLHSRAAE PLAVARWEVF DVADAVRRHR QEPRATRAFC LLLRSVAGPS QGPLALRLLG
FGSRDRGRAA AEERALLVVS SRTQRKGSLF REIRAQARAL GAALAAEPAE QPLDPGPGTG
SPTAVIGGRR RRRTALAGAR AAQGSGGGAG RGHGRRGRSR CSRRPLHVDF KELGWDDWII
APLDYEAYHC EGVCDFPLRS HLEPTNHAII QTLLNSMAPD AAPASCCVPA RLSPISILYI
DAANNVVYKQ YEDMVVEACG CR
//
