ID   M3YQY9_MUSPF            Unreviewed;       993 AA.
AC   M3YQY9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSMPUP00000013748.1};
DE   SubName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform X5 {ECO:0000313|RefSeq:XP_004757335.2};
GN   Name=GARNL3 {ECO:0000313|Ensembl:ENSMPUP00000013748.1,
GN   ECO:0000313|RefSeq:XP_004757335.2};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013748.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000013748.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004757335.2}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004757335.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AEYP01042664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01042665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01042666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01042667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004757335.2; XM_004757278.3.
DR   STRING; 9669.ENSMPUP00000013748; -.
DR   Ensembl; ENSMPUT00000013965.1; ENSMPUP00000013748.1; ENSMPUG00000013851.1.
DR   GeneID; 101680698; -.
DR   CTD; 84253; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   GeneTree; ENSGT00940000159362; -.
DR   HOGENOM; CLU_008685_1_0_1; -.
DR   OMA; FEGYSER; -.
DR   OrthoDB; 25782at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   DOMAIN          169..385
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          467..778
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          789..826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          891..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..807
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        891..918
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        924..945
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   993 AA;  110593 MW;  D131971AD982A315 CRC64;
     MKSSVSEDLG CRRGDFSRKH YGSVELLISS DADGAIQRAG RFRVENGSSD ENATALPGTW
     RRTDVHLENP EYHTRWYFKY FLGQVHQNYI GNDAEKSPFF LSVTLSDQNN QRVPQYRAIL
     WRKTGTQKIC LPYSPTKTLS VKSILSAMNL DKFEKGPREI FHPEIQKDLL VLEEQEGSVN
     FKFGVLFAKD GQLTDDEMLS NEIGSDAFQK FLNLLGDKIT LKGWTGYRGG LDTKNDTTGT
     HSVYTVYHGH EIMFHVSTML PYSKENKQQV ERKRHIGNDI VTIVFQEGEE PSPAFKPSMI
     RSHFTHIFAL VRYDQQNDNY RLKIFSEESV PLFGPPLPSP PVFTDHQEFR DFLLVKLING
     EKATLETPTF AQKRRRTLDM LIRSLYQDLM PDLHKNMLNR RSFSDVLPES PKSARKKEEA
     RQAEFVRIGQ ALKLKSIVRG DAPSSLVASG ICKKEPWEPQ CFCSDFPYEA VCADPWGQAL
     LVSTDAGVLL VDDDLPSVPV FDKTLPVKQM HVLETLDLLI LRADKGKDAR LFVFRLSAVH
     KAIESKQPVK SRCDCRDNKL EKTKGCHLYA INTHHSRELR IVVAIRNKLL LITRKHNKPG
     GLAGISLLSP LSESPVEEFQ YIREICLSDS PAVMTLVDGP TEESDNLICV AYRHQFDVVN
     ESTGEAFRLH HVEANRVNFV AAIDVYEDGE AGLLLCYNYS CIYKKVCPFN GGSFLVQPSA
     SDFQFCWNQA PYAIVCAFPY LLAFTTDSME IRLVVNGNLV HTAVVPQLQL VASRSDIYFT
     ATTAVNEVSS GGSSKGASAH NSPQTPPGRD TPVFPSSLGE GETPSKNLYK IPLRNLVGRS
     IERPLKSPLV SKAVTPPTAI GLGIAAIPVT HSLSLSRMEI KEIASRTRRE LLGLSDEAGP
     RSEGAPKPKS KARKQLEESQ GGPKPGTARS TSSDRITTAS LESPSAPEAN PEGRYHSTGS
     DQDPVADREG SPVWGSSPFQ LTASSDEDII DLK
//