ID M3YR02_MUSPF Unreviewed; 4731 AA.
AC M3YR02;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Dynein axonemal heavy chain 8 {ECO:0000313|Ensembl:ENSMPUP00000013761.1};
GN Name=DNAH8 {ECO:0000313|Ensembl:ENSMPUP00000013761.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013761.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013761.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AEYP01006320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004740044.1; XM_004739987.2.
DR RefSeq; XP_004740045.1; XM_004739988.2.
DR STRING; 9669.ENSMPUP00000013761; -.
DR Ensembl; ENSMPUT00000013978.1; ENSMPUP00000013761.1; ENSMPUG00000013864.1.
DR KEGG; mpuf:101682048; -.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000158992; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR InParanoid; M3YR02; -.
DR OMA; IAYEYMK; -.
DR OrthoDB; 166463at2759; -.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 2082..2226
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2363..2516
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2689..2837
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3315..3388
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3542..3576
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 36..55
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4731 AA; 541288 MW; 189C4ABA60B881D7 CRC64;
MSAEEGGSPP PEEPAPPSSG DTVPPGSEGT GQRDPGDEPP PSPGEEAPPP SDEGPLHPAT
EAASALDDGS RSEIGPVLSP SDYLNLIPSD ERIILPEDEE LDAHRVRAKP TLRLGQSMLS
DMLSQSSHRS SRYRRSMSGI PNLQETLKER QARFRDAREN RKMKIDPSYK YIFEILAEKL
GLDLVTVEEL VLDCPSLEAF THFFMKDGCK TLKFLYQEGD VPGLECGRTI AGATKGAKMM
RLYIDNAAPE KLKGLCIFFV RCHSDIAINI KNIHEEVLFT VLDASTGILN GIKNMLSSVF
LPAILATNNW GALNQSKQGE SEKHIFTETI SRYLSFLDGA RVSIEGTVML KKVDNIDFSK
LHTFEEVTAA ASNSETVRQL EEVLMTWYKQ IEQVLIESEQ MRKEADDSGP LTELEHWKRM
SAKFNYIIEQ IKGPTCKAVI NVLNVAHSKL LKNWRDLDAR ITDTANESKD NVRYLYTLEK
VCQPLYNYDL VSMAHGIQNL INAIRMIHSV SRYYNTSERM TSLFIKVTNQ MVTACKAYIT
DGGTIHVWDQ ETPLVLKKIQ DCIFLFKEYQ TSFHKTRKQI LESSGEKSFE VSEMYIFGKF
EAFCKRLEKI TEMITIVQMY SALSNSTIEG IDIMSIKFKN IYQGVKKKQY DILDPRRTEF
DIDFTEFMTK INGLEIQIQA FMNSTFGKIL SSQQALQLLQ RFQKLQIPCL QSEINHTIER
ILQFYVSELE ATKKLYHSQK DDPPLARNMP PIAGKILWVR QLYRRISEPI NYFFKNSEIL
SSAEGKAVIR QYNKISYVLV EFEVVYHTAW VREISQLQYA LQATLFVRHP ETGKLLVNFD
PKILEVVRET KCMIKMKLDV PEQAKKLLKL ESKLKADKLH LQGLLQYYED LCQEVPSVFV
NLMTPKMKKV ESVLRQGLTI LTWSSLTLET FFKEVDSVLN MFNQLLKKIS DLCEMHIDTV
LKEIAKTVLI SLPEGGATKV EDMLTLNETY TKEWADVLNH KSKHVEEAVK ELILIFENIY
EVKYSGKTAK PLPEQRKHVV FGSETEEGES TDYEANIIPE VDVNDKEDEF KKECKEVYAF
FSHQLLDSLQ KATRLSLDTM KRRIFVSSHH GRRQSEDIIS FIKTEVHLAI PNVVMIPSLD
DIQQAINRMI QLTLEVSRGV AHWGQQQTRN IKPGITSPSR TAPDVTPVNA AKLAKKEERS
FEEIIPARKL KNFYPGVAEH KDISKLVLLL SSSVNSLRKV AHEALQDFQK YKTLWTEDRD
VKVKEFLANN PSLTEIRSEI LHFATFEQEI DELKPVIFVG ALEMHTEPMK LALSIEAKAW
KMLLCRYLNE EYKKKMSDMI AFINEYLKKL SRPIRDLDDV RFAMEALSSI RDNEIQMDMT
LGPIEEAYAI LNRFEVEVTK EESEAVDTLR YSFNKLQSKA VSVQDELVQV QPKFKSSLLE
AVEVFREDVM NFAESYETEG PMVPNIPPQE ASNRLQIFQA NFDDLWRKFV TYSSGEQLFG
LPVTDYEVLH KTRKELNLLQ KLYGLYDTVM NNISGYYEIL WGDVDIESIN AELQEFQNRC
RKLPKGLKDW QAFLDLKKRI DDFSESCPLL EMMTNKAMKQ RHWDRISELT GTPFDVESDS
FCLRNIMEAP LLKHKDDIED ICISAIKEKD IEAKLTQVIE NWTNQNLSFA AFKGKGELLL
KGTESGEIIT LMEDSLMVLG SLLSNRYNAP FKKTIQSWVY KLSTSSDIIE EWLVVQNLWV
YLEAVFVGGD IAKQLPQEAK RFQNIDKSWM KIMQRAHENP NVISCCVGDE TMGQLLPHLH
EQLEVCQKSL TGYLEKKRLL FPRFFFVSDP VLLEILGQAS DSHTIQPHLP AVSDNINEVT
FHAKDYDRIL AVISREGEKI ILDNPIMAKG PVEIWLMDLL KMQMSSLHNI IRSAFYQISD
SGFQLLPFLN HFPAQVGLLG IQMLWTHDSE EALNNAKDDR KIMHVTNQKF LDILNILIGQ
TTHDLSKFDR VKFETLITIH VHQRDIFDDL VKMHIRSVTD FEWLKQSRFY FKEDLDQTVV
SITDVDFIYQ NEFLGCTDRL VITPLTDRCY ITLAQALGMN MGGAPAGPAG TGKTETTKDM
GRCLGKYVVV FNCSDQMDFR GLGRIFKGLA QSGSWGCFDE FNRIELPVLS VAAQQIYIVL
TARKERKKQF IFSDGDCVDL NPEFGIFLTM NPGYAGRQEL PENLKIQFRT VAMMVPDRQI
IMRVKLASCG FLENVILAQK FYVLYKLCEE QLTKQVHYDF GLRNILSVLR TLGAQKRARP
EDSELSTVMR GLRDMNLSKL VDEDEPLFLS LINDLFPGLQ LDSSTHVELQ AAVANQVQIE
GLINHPPWNL KLVQLYETSL VRHGLMTLGP SGSGKTTVIT ILMKALTECG RPHREMRMNP
KAITAPQMFG RLDTATNDWT DGIFSTLWRK TLKAKKGENI FLILDGPVDA IWIENLNSVL
DDNKTLTLAN GDRIPMAPNC KLLFEVHNIE NASPATVSRM GMVYISSSAL SWKAILQAWL
KKRSAQEATV FLGLYNKIFE DIYTYMKLNL NPKMQLLECN YIMQSLNLLE GLIPSKEEGG
ISCVEHLHKL FVFGLMWSLG ALLELESREK LEAFLRNHES KLDLPEIPKG TSQTMYEFYV
TDYGDWEHWN KKLQPYYYPT DSIPEYSSIL VPNVDNVRTN FLIDTIAKQQ KAVLLTGEQG
TAKTVMIKAY LKKYDPEVQL SKSLNFSSAT EPIMFQRTME SYVDKRMGST YGPPGGRKMT
VFIDDINMPV INEWGDQITN EIVRQMMEME GMYSLDKPGD FTTIVDVQII AAMIHPGGGR
NDIPQRLKRH FTVFNCTLPS NASIDKIFGI IGCGYFDPCR KFKPEVCDMI ANLVSAGRVL
WQWTKMKMLP TPSKFHYIFN LRDLSRIWQG MLTIKAEECD SISILLSLFK HECNRVIADR
FITPEDEQWF NIHLVRAVEE NINPDVTSYI LPEPYFVDFL HEMPEPTGDE PEDTIFEVPK
IYELVPSFDF LSEKLQFYQR QFNEIIRGTS LDLVFFKDAM THLIKISRIV RTSCGNALLV
GVGGSGKQSL SRLASFIAGY QIFQITLTRS YNVNNLTDDL KYLYKVAGAD GKGITFIFTD
NEIKDEAFLE YLNNLLSSGE ISNLFARDEM DEITQGLISV MKKEMPRHPP TFDNLYEYFI
SRSRKNLHVV LCFSPVGEKF RARSLKFPGL ISGCTMDWFS RWPKEALIAV ASYFLSGYNI
VCSSDTKRQV VETMGLFHDM VSESCENYFQ RYRRRAHVTP KSYLSFINGY KNVYTEKVKH
INEQAERMNI GLDKLMEASE SVAKLSQDLA IKEKELAVAS VKADEVLAEV TVSAQASAKV
KNEVQEVKDK AQKIVDEIDS EKVKAETKLE AAKPALEEAE AALNTIKPND IATVRKLAKP
PHLIMRIMDC VLLLFQKKID PVTMDPEKPC CKPSWGESLK LMSATGFLWS LQQFPKDTIN
EETVELLQPY FNMDDYSLEN AKKVCGNVAG LLSWTLAMAT FYGINREVLP LKANLAKQEG
RLAVANIELG KAQELLDEKQ AELDKVQAKF DAAMSEKMDL VNDADMCRKK MQAASTLIDG
LSGEKVRWTQ QSKEFKAQIN RLVGDILLCT GFLSYLGPFN QIFRNYLLKD QWEIELRARK
IPFTENLNLI SMLVDPPTIG EWGLQGLPGD DLSIQNGIIV TKATRYPLLI DPQTQGKTWI
KSKERENDLQ VTSLNHKYFR THLEDSLSLG RPLLIEDISE ELDPVLDNVL EKNFIKSGTT
FKVKVGDKEC DLMVTFKLYI TTKLPNPAFT PEINAKTSVI DFTVTMKGLE NQLLRRVILT
EKQELESERV KLLEDVTFNR RKMKELEDNL LYKLSATKGS LVDDESLIGV LRTTKHTAAE
VSEKLHVAAE TEIKINTAQE EFRPAATRGS ILYFLITEMS MVNIMYQTSL AQFLKLFDQS
MARSEKSPLP QKRITNIIEY LTYEVFIYSV RGLYENHKFL FVLLMTLKID LQRGTVKHRE
FQALIKGGAA LDLKACPPKP FRWILDMTWL NLVELSKLPQ FAEIMNQISR NEKGWKSWFD
KDTPEEEIIP DGYNDSLDTC RKLLLIRSWC PDRTVFQARK YIADSLEEKY TEPVILNLEK
TWEESDTRTP LICFLSMGSD PTIQIDALAK KLKLECRTIS MGQGQEVHAR KLIQMSMQQG
GWVLLQNCHL GLEFMEELLE TLITTEANDD SFRVWITTEP HNRFPITLLQ TSLKFTNEPP
QGMRAGLKRT FAGINQDLLD ISNLPMWKPM LYTVAFLHST VQERRKFGPL GWNIPYEFNS
ADFAASVQFI QNHLDECDIK KGVSWSTVRY MIGEVQYGGR VTDDFDKRLL NCFARVWFSE
KMFEPSFCFY TGYKIPLCKT LDQYFEYIQS LPSLDNPEVF GLHPNADITY QSNTASAVLE
TITNIQPKES GGGVGETREA IVYRLSEDML SKLPPDYIPH EVKARLIKMG HLNSMNIFLR
QEIDRMQKVI SILRSSLSDL KLAIEGTIIM SENLRDALDN MYDARIPQIW KRVSWDSSTL
GFWFTELLER NAQFSTWIFE GRPNAFWMTG FFNPQGFLTA MRQEVTRAHK GWALDSVTIH
NEVLRQTKEE ITLPPMEGVY IYGLYMDGAA WDRRNGKLTE STPKVLFTQL PVLHIFAINS
TAPKDPKLYV CPIYKKPRRT DLTFITVVYL RTVLSPDHWI LRGVALLCDI K
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