ID M3YR59_MUSPF Unreviewed; 531 AA.
AC M3YR59;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Protein arginine N-methyltransferase 3 isoform X1 {ECO:0000313|RefSeq:XP_004752192.1};
DE SubName: Full=Protein arginine methyltransferase 3 {ECO:0000313|Ensembl:ENSMPUP00000013818.1};
GN Name=PRMT3 {ECO:0000313|Ensembl:ENSMPUP00000013818.1,
GN ECO:0000313|RefSeq:XP_004752192.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013818.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013818.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004752192.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004752192.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01030559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01030567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004752192.1; XM_004752135.3.
DR STRING; 9669.ENSMPUP00000013818; -.
DR Ensembl; ENSMPUT00000014038.1; ENSMPUP00000013818.1; ENSMPUG00000013923.1.
DR GeneID; 101672701; -.
DR KEGG; mpuf:101672701; -.
DR CTD; 10196; -.
DR eggNOG; KOG1499; Eukaryota.
DR GeneTree; ENSGT00940000156825; -.
DR HOGENOM; CLU_017375_6_2_1; -.
DR OMA; DGWAVWF; -.
DR OrthoDB; 197898at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:1900053; P:negative regulation of retinoic acid biosynthetic process; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049482; ANM3-like_C2H2_Zf.
DR InterPro; IPR049009; ANM3_Znf-C2H2.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11006:SF114; PROTEIN ARGININE N-METHYLTRANSFERASE 3; 1.
DR Pfam; PF21137; ANM3_C2H2_Zf; 1.
DR Pfam; PF21336; ANM3_zf-C2H2; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01015}.
FT DOMAIN 50..71
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 59844 MW; 638AE547F776CEED CRC64;
MCSLASGAAG GRGAVEDEDD LPELSDSGDE AAWEDEDDAE PPHDKQQTPC LFCDRLFTSA
EETFSHCKSE HQFNIDNMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY
LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMETRAL SAEAALARAR
EDLQRMKQFA QDFVMNADVR TCSSSTTAIA DLQEDEDGVY FSSYGHYGIH EEMLKDKVRT
ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VFGVDQSEIL YQAMDIIRLN
KLEDTITLIK GKIEEVCLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP
DICTISLVAV SDMNKHADRI AFWDNVYGFN MSCMKKAVIP EAVVEVLDPK TLISDACSIK
QIDCHTTSVS ALEFSSDFTL QITKTSMCTA IAGYFDIYFE KNCHSRVVFS TGPQSAKTHW
KQTIFLLEKP FSVKAGEALK GRITVHKNKK DPRSLIVTLT LNNSTQTYGL Q
//
