ID M3YSC3_MUSPF Unreviewed; 100 AA.
AC M3YSC3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Apolipoprotein A-II {ECO:0000256|ARBA:ARBA00022421};
DE AltName: Full=Apolipoprotein A2 {ECO:0000256|ARBA:ARBA00030900};
GN Name=APOA2 {ECO:0000313|Ensembl:ENSMPUP00000014233.1,
GN ECO:0000313|RefSeq:XP_004775983.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014233.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000014233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004775983.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004775983.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May stabilize HDL (high density lipoprotein) structure by its
CC association with lipids, and affect the HDL metabolism.
CC {ECO:0000256|ARBA:ARBA00003879}.
CC -!- SUBUNIT: Monomer. Interacts with NAXE and NDRG1.
CC {ECO:0000256|ARBA:ARBA00025881}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A2 family.
CC {ECO:0000256|ARBA:ARBA00010232}.
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DR EMBL; AEYP01088011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004775983.1; XM_004775926.3.
DR STRING; 9669.ENSMPUP00000014233; -.
DR Ensembl; ENSMPUT00000014461.1; ENSMPUP00000014233.1; ENSMPUG00000014342.1.
DR GeneID; 101675396; -.
DR KEGG; mpuf:101675396; -.
DR CTD; 336; -.
DR eggNOG; ENOG502SVYZ; Eukaryota.
DR GeneTree; ENSGT00390000003306; -.
DR HOGENOM; CLU_157351_0_0_1; -.
DR OMA; LTICSFE; -.
DR OrthoDB; 4610750at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0042627; C:chylomicron; IEA:Ensembl.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0034190; F:apolipoprotein receptor binding; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0070653; F:high-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0046340; P:diacylglycerol catabolic process; IEA:Ensembl.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:Ensembl.
DR GO; GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0060621; P:negative regulation of cholesterol import; IEA:Ensembl.
DR GO; GO:0002719; P:negative regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR GO; GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:Ensembl.
DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0050996; P:positive regulation of lipid catabolic process; IEA:Ensembl.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR GO; GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IEA:Ensembl.
DR Gene3D; 6.10.250.100; -; 1.
DR InterPro; IPR006801; ApoA-II.
DR InterPro; IPR036172; ApoA-II_sf.
DR PANTHER; PTHR11027; APOLIPOPROTEIN A-II; 1.
DR PANTHER; PTHR11027:SF0; APOLIPOPROTEIN A-II; 1.
DR Pfam; PF04711; ApoA-II; 1.
DR SUPFAM; SSF82936; Apolipoprotein A-II; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW HDL {ECO:0000256|ARBA:ARBA00022850};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..100
FT /note="Apolipoprotein A-II"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198568"
SQ SEQUENCE 100 AA; 11302 MW; AAF255367835303D CRC64;
MKLLALTLLL LAVCNLEGAL VRRQAEEPDL QSLISQYSEM VATYGKNLVE KVKDPELQAQ
AKAYFENTQE QLMPLVQKVG VDLINFLSNF MDFKKQPATQ
//
