ID M3YT39_MUSPF Unreviewed; 452 AA.
AC M3YT39;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Tubulin/FtsZ 2-layer sandwich domain-containing protein {ECO:0000259|SMART:SM00865};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014499.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000014499.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636}.
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DR EMBL; AEYP01095580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01095589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YT39; -.
DR Ensembl; ENSMPUT00000014732.1; ENSMPUP00000014499.1; ENSMPUG00000014609.1.
DR GeneTree; ENSGT00940000154457; -.
DR HOGENOM; CLU_015718_0_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF462; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 258..394
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51584 MW; BCDCD9E4414F469F CRC64;
RECISIHVGQ AGVQIGNACW ELYCLEHGIQ PDGQMPSDKT IGGGDDSFNT FFSETGAGKH
VPRAVFVDLE PTVIGELASV TCSVYSHIQL LTYALKHNAL LQTQAVHFSD GFEVFEIHLL
ESEFKLMEIR KNLKHVIVFH NYNKDLNQGG KKSLKIAFNI EYSATDKFTE FSLPPVVYVS
ILTVASHHSI ISNHFSHSCR YMVRDIALYQ IKRANMKVNP VFLKINYSMI LTEILSIIRK
CSNYNSSLSV LLQDFEEIYL SYRQLNFYPM FGYQILILDI KKFHSQNLIY SITSMCIDKF
NKFNLCDPAV SKYFTYCFLY TRDKVKAEVK MEVVEIKGKR PSQFRDWCPT GFKVGINYQP
PTVVPGGDLA KVQRAVCMLS NTTAIAEAWA RLDHKFDLMY AKRAFVHWYV GEGMEEGEFS
EAREDMAALE KDYEEVGVDS VEGEGEEEGE EY
//
