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Database: UniProt
Entry: M3YT51_MUSPF
LinkDB: M3YT51_MUSPF
Original site: M3YT51_MUSPF 
ID   M3YT51_MUSPF            Unreviewed;      3137 AA.
AC   M3YT51;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-MAY-2019, entry version 48.
DE   SubName: Full=Laminin subunit alpha 2 {ECO:0000313|Ensembl:ENSMPUP00000014511};
GN   Name=LAMA2 {ECO:0000313|Ensembl:ENSMPUP00000014511};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014511, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000014511}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000014511};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000014511}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AEYP01006796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9668.ENSMPUP00000014511; -.
DR   Ensembl; ENSMPUT00000014744; ENSMPUP00000014511; ENSMPUG00000014620.
DR   eggNOG; KOG1836; Eukaryota.
DR   eggNOG; ENOG410XRDC; LUCA.
DR   GeneTree; ENSGT00940000155362; -.
DR   InParanoid; M3YT51; -.
DR   OMA; FGPCNCK; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 2.
DR   Pfam; PF00053; Laminin_EGF; 16.
DR   Pfam; PF00054; Laminin_G_1; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00180; EGF_Lam; 16.
DR   SMART; SM00281; LamB; 2.
DR   SMART; SM00282; LamG; 5.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 6.
DR   PROSITE; PS50027; EGF_LAM_2; 15.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR   PROSITE; PS51115; LAMININ_IVA; 2.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   3137       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004045375.
FT   DOMAIN       52    303       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      304    360       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      361    430       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      431    485       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      486    534       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      555    740       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN      774    823       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      824    881       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      882    934       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      935    983       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      984   1030       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1031   1076       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1077   1122       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1123   1182       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1197   1396       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1437   1485       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1486   1543       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1544   1590       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2160   2343       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2355   2536       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2541   2725       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2778   2949       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2954   3134       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED       22     46       {ECO:0000256|SAM:Coils}.
FT   COILED     1650   1670       {ECO:0000256|SAM:Coils}.
FT   COILED     1699   1719       {ECO:0000256|SAM:Coils}.
FT   COILED     1724   1774       {ECO:0000256|SAM:Coils}.
FT   COILED     1807   1862       {ECO:0000256|SAM:Coils}.
FT   COILED     1884   1904       {ECO:0000256|SAM:Coils}.
FT   COILED     1952   1972       {ECO:0000256|SAM:Coils}.
FT   COILED     2051   2092       {ECO:0000256|SAM:Coils}.
FT   COILED     2107   2155       {ECO:0000256|SAM:Coils}.
FT   DISULFID    326    335       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    398    407       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    431    443       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    461    470       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    505    514       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    793    802       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    852    861       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    906    915       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    918    932       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    935    947       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    937    954       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    956    965       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    984    996       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1004   1013       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1049   1058       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1077   1089       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1079   1096       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1098   1107       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1123   1135       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1153   1162       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1456   1465       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1514   1523       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1544   1556       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1546   1563       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1565   1574       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2698   2725       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   3137 AA;  346023 MW;  2A7AEAE2047A7612 CRC64;
     MPGAAGVLLV LLLSGGLGGG QHQQQQQQQQ QQQQQQQQQQ QQQRQRQSQA HQQRGLFPAV
     LNLASNALIT TNATCGEKGP EMYCKLVEHV PGQPVRNPQC RICNQNSSNP NQRHPITNAI
     DGKNTWWQSP SIKNGIEYHY VTITLDLQQV FQIAYVIVKA ANSPRPGNWI LERSLDNVEY
     KPWQYHAVTD TECLTLYNIY PRTGPPSYAK DDEVICTSFY SKIHPLENGE IHISLINGRP
     SADDPSPELL EFTSARYIRL RFQRIRTLNA DLMMFAHKDP REIDPIVTRR YYYSVKDISV
     GGMCICYGHA RACPLDPVTN KSRCECEHNT CGDSCDQCCP GFHQKPWRAG TFLTKTECEA
     CNCHGKAEEC YYDENVARRN LSLNIHGKYI GGGVCINCTQ NTAGINCETC IDGFFRPKGV
     SPNYPRPCQP CHCDPIGSLN EVCVKDEKHA RRGLAPGSCH CKPGFTGVSC DRCARGYTGY
     PECKPCNCSG AGSTNEDPCF GHCHCKENVE GGDCSRCKAG FFNLQEDNHK GCDECFCSGV
     SDRCQSSYWT YGHIQDMRGW YLTDISGHVQ VAPQQDDLDL PQQISIRSEE AHRALPQGHY
     WSAPAPYLGN KLTAAGGQLT FTISYDFEEE EEDTERVLQI VVILEGNDLR IGTAQDEAYL
     QPYEEHTHVL SLKEELFTIH GTNSPVSRRE LMTVLANLKR VLIQITYSLG MDAIFRLGSV
     GLESAVPYPT DGSLATAVEV CQCPPGYTGS SCESCWPQHR RVNGTIFGGI CEPCQCFGHA
     ESCDDITGEC LNCKNHTGGP YCNKCLPGYY GDPSKGTSED CQPCACPLNI PSNNFSPTCH
     LDRSLGMICD ACPVGYSGPR CERCAEGYFG QPSVPGGSCQ PCQCNDNLDF SIPGSCDSLS
     GSCLICKPGT TGRFCELCAD GYFGDAVDAK NCQPCRCHVN SSFSERCDAR TGQCECKPNV
     QGRRCDECKP ETFGLQSGRG CVPCNCNSFG SKSFDCEESG QCWCQPGVTG KKCDRCARGY
     FNFQEGGCTA CACSHLGNNC DPKTGQCICP PNTIGEKCSR CAPNTWGHSI TTGCKACNCS
     TVGSLDFQCN INTGQCSCHP KFSGARCTEC NRGHWNYPHC SPCECFLPGT DDRTCDSETK
     KCSCIDQTGQ CTCKVNVEGI HCDRCRPGKF GLDAKNPLGC SNCYCFGVTT QCSEAKGLIR
     TWVTLQPEQT ILPLVDEALQ HTTTKGIVFQ HPEIVAHMDL VRQELRLEPY YWKLPEQFEG
     KKLMAYGGKL KYAIYFEARE ETGFSTYNPQ VIIRGGTPTH ARIIVRHMAA PLIGQLTRHE
     IEMTEKEWKY YGDDPRISRT VTREDFLDII YDIHYILIKA TYGNIMRQSR ISEISMEVAE
     QGGITAVTPP ARLIERCDCP PGYSGLSCET CMPGFYRLQS EPGSHTPRPT LGTCVPCQCN
     GHSTLCDPET SKCQNCQHHT AGDFCERCAL GYYGIVRGLP NDCQQCACPL ISSSNNFSPS
     CVMQGLDDYR CTACPRGYEG QYCERCAPGY TGSPSSPGGS CQECECDPHG SLPVPCDPIT
     GLCTCRPGAT GPKCDCCKHW HAREGMECVF CGDECTGLLL GDLARLEQMA MSINLTGPLP
     APYKMLYGLE NMTQELKHLL SPQRAPERLI QLAEGNLNML VSEMNELLTR ATKVTADGEQ
     TGQDAERTNK RADSLGEFIK ELAQDAEAVN EKAVRLNETL GTQDKAFERN LQALQKEIDQ
     MMAELRRKNL DKQKEVAEDE LVAAEGLLKK VKKLFGESRG KNEEMEKGLQ MILADYKDRV
     DDAWDLLREA MEKIREANRL SAANQKNMTA LEKKKEAIER GKQQTENTLK EGNDILDEAN
     RLAGEINSVI DYVEDIQTKL PPMSEELKDK IDDLAQEIKD RNLAEKVSRA ESHAAQLNDS
     SAVLDGILDE AKNISFNATA AFNAYSHIKD SIDEAEKIAQ EAKGLAHEAT KLATGPQGSL
     REGAKGSLQK SFGVLNEAKK LANAIKENDD YLNGLITRLE NADVRNEDLL RALNDTLGKL
     SAIPNDTAAK LQAIKDKARQ ANDTAKDVLA QIKDLHQNLD GLKKNYNQLA DSVAKTNAVL
     KDPSKNIADA DATVKNLEQE ADRLIDKLKP IKELEDNLKK NISEIKELIN QARKQANSIK
     VSVSSGGDCI RTYKPEIKKG SYNNIIVNVK TAVADNLLFY LGSAKFIDFL AIEMRKGKVS
     FLWDVGSGVG RVEYPDLTID DSYWYRIEAS RTGRNGTISV RALDGPKASI VPSTYYAASP
     PGYTILDVDA NAMLFVGGLT GKLKKADAVR VITFTGCMGE TYFDSKPIGL WNFREKEGDC
     KGCTVSPQVE DSEGTIQFDG EGYALVSRPI RWYPNISTVM FKFRTFSSSA LLMYLATRDL
     KDFMSVELTD GHIKVSYDLG SGMASVVSKQ NHNDGKWKSF TLSRIRKQAN ISIVDIDSNQ
     EENIATSSSG NNFGLDLKAD DKIYFGGLPT LRNLSMKARP EVNLKKYSGC LKDIEISRTP
     YNILSSPDYV GVTKGCSLEN VYTVSFPKPG FVELAPVPID VGTEINLSFS TKNESGIILL
     GSGGTPVQPR RKRRQTGQAY YAIFLNKGRL EVHLSTGTRT MRKIVIKPEP SLFHDGREHS
     VHVERTKGIF TVQVDEDRRH MQNLTVEQAI EVKKLFVGGA PPEFQPPPLR NIPSFEGCVW
     NLVINSVPMD FAQPVSFKNA DIGRCAHQKP REEEEGAVPA EIVTQPEPVP TPAFPIPTPT
     VAHGPCGTES EPALLIGSKQ FGLSRNSHIA IAFDDTKVKN RLTIEFEVRT EAESGLLFYM
     ARINHADFAT VQLRNGFPYF SYDLGSGDTN TMIPTKINDG QWHKIKIVRI KQEGIIYVDD
     ASNRTVSPKK ADILDVVGML YVGGLPINYT TRRIGPVTYS IDGCIRNFQM VEAPADLEQP
     TSSFHVGTCF ANAQKGTYFD GTGFAKAVGA FKVGLDLLVE FEFRTTRTTG VLLGISSQKM
     DGMGIEMIDE KLMFHVDNGA GRFTAVYDAG IPGHLCDGKW HKVTANKIKH RIELTVDGNQ
     VEAQSPNQAS TSADTNDPVF VGGFPDGLNQ FGLTTSVRFR GCIRSLRLTK GTGKPLEVNF
     AKALELWGVQ PVSCPVN
//
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