ID M3YW48_MUSPF Unreviewed; 1249 AA.
AC M3YW48;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Cohesin subunit SA {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=SCC3 homolog {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=Stromal antigen {ECO:0000256|RuleBase:RU369063};
GN Name=STAG3 {ECO:0000313|Ensembl:ENSMPUP00000015558.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000015558.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000015558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Component of cohesin complex, a complex required for the
CC cohesion of sister chromatids after DNA replication. The cohesin
CC complex apparently forms a large proteinaceous ring within which sister
CC chromatids can be trapped. At anaphase, the complex is cleaved and
CC dissociates from chromatin, allowing sister chromatids to segregate.
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBUNIT: Part of the cohesin complex which is composed of a heterodimer
CC between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached
CC via their hinge domain, and RAD21 which link them at their heads, and
CC one STAG protein. {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369063}.
CC Chromosome {ECO:0000256|RuleBase:RU369063}. Chromosome, centromere
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SIMILARITY: Belongs to the SCC3 family. {ECO:0000256|ARBA:ARBA00005486,
CC ECO:0000256|RuleBase:RU369063}.
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DR EMBL; AEYP01053095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01053096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01053097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01053098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004761546.1; XM_004761489.2.
DR AlphaFoldDB; M3YW48; -.
DR STRING; 9669.ENSMPUP00000015558; -.
DR Ensembl; ENSMPUT00000015799.1; ENSMPUP00000015558.1; ENSMPUG00000015668.1.
DR KEGG; mpuf:101689444; -.
DR eggNOG; KOG2011; Eukaryota.
DR GeneTree; ENSGT00950000182972; -.
DR HOGENOM; CLU_005067_1_0_1; -.
DR InParanoid; M3YW48; -.
DR OMA; WDCAAPL; -.
DR OrthoDB; 5354237at2759; -.
DR GO; GO:0000785; C:chromatin; IEA:UniProtKB-UniRule.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0030893; C:meiotic cohesin complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000802; C:transverse filament; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0034502; P:protein localization to chromosome; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039662; Cohesin_Scc3/SA.
DR InterPro; IPR020839; SCD.
DR InterPro; IPR013721; STAG.
DR PANTHER; PTHR11199:SF8; COHESIN SUBUNIT SA-3; 1.
DR PANTHER; PTHR11199; STROMAL ANTIGEN; 1.
DR Pfam; PF21581; SCD; 1.
DR Pfam; PF08514; STAG; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51425; SCD; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU369063};
KW Cell division {ECO:0000256|RuleBase:RU369063};
KW Chromosome {ECO:0000256|RuleBase:RU369063};
KW Chromosome partition {ECO:0000256|RuleBase:RU369063};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369063}.
FT DOMAIN 321..406
FT /note="SCD"
FT /evidence="ECO:0000259|PROSITE:PS51425"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..92
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 140716 MW; 15F77E2E2D712AF5 CRC64;
MPTLRSSSSP SSVSSPLRRA AGGGQRGLSA SSSSSVSVPY GNRDSGQTSQ GDSDSLSADE
GSDFEDSLRR SVRKRAARRP LKTTPVAKHP KKGSRMIRGD GQKDSEVPAS HLFDAVKAAK
SDMQSLVDEW LDSYKQDQDA GFLELINFFI RSCGCKGNVT PEMFKKMSNS EIIRHLTEQF
NEDSGDYPLT APGPSWKKFQ GSFCEFVKTL VFQCQYSLLY DGFPMDNLIS LLTGLSDSQV
RAFRHTSTLA AMKLMTSLVR VALQLSLHKD NNQRQYEAER NKGPGQRAPE RLESLLEKRK
ELQEHQEEIE GMMNALFRGV FVHRYRDVLP EIRAICIEEI GSWMQSYSTS FLTDSYLKYI
GWTLHDKHRE VRLKCLKALK ALYSSRDLTA RLELFTSRFK DRMVSMVMDR EYDVAVEAVK
LLTIILKNME GVLTDADCEG IYPVVYASHR ALASAAGEFL YWKLFYPECE TRAEGGRQRR
RSPRAQRTFF HLLLSFFVES ELHDHAAYLV DSLWDCAGAQ LKDWESLTSL LLEKDQSACR
VTAGGGGLSP PNLGDVQEST LIEILVSSVR QASEGHPPVG RLTGKKGLTP KERKTQADDK
VKLTEHLIPL LPQLLAKFSA DAEKVAPLLQ LLNHFDLNIY CTRRLEKHLE LFLQQLQEVV
VKHAEPAVLE AGAHALYLLC NPEFTFFGRV DFARSQLVDL LTDRFQQELE ELLQSPFLDE
DEVYSLAATL KRLSAFYNAH DLSRWELYEP CYRLLRKAVD TGEVPHQVIL PALTLVYFSI
LWTLSHLSES DASQKQLLSL KGRVVAFCEL CQSCLSDVDS DIQEQAFVLL SDLLLVFSPQ
MILGGRDFLR PLVFFPEATL QSELASFLMD HVFIQPGELG SGHSQEDHVH IEQLHQRRRL
LAGFCKLLLY GVLEMDAASD VFKHYNKFYN DYGDIIKETL TRARQIDRSH CSRILLLSLK
QLYTELLQEQ GPQGLNELPA FGEMRDLARR FALSFGPQQL QNRDLVVALH KEGIRFSLSE
PPPAGSSGQP PNLAFLELLS EFSPRLFHQD KQLLLSYLGK GLQRVSQSLD CPWGPVTTYC
HSLSPVESTA EASPQGYPRS KKRRTEGPPR RQREDVRPSQ EESLQLTSIP PSPTLTSTAV
KRGQPQRALG EAEEEGSSEP EHSAQGSQPL SGNQRPRFSS PRRFRTLLHP PGPGLGSRLT
RLSLMEEDED ELEAHSELSE GWQDADKHSS PSEHGLDLLD STELNLEDF
//
