ID M3YWR2_MUSPF Unreviewed; 440 AA.
AC M3YWR2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=E2F transcription factor 2 {ECO:0000313|Ensembl:ENSMPUP00000015772.1};
DE SubName: Full=Transcription factor E2F2 isoform X2 {ECO:0000313|RefSeq:XP_004741260.1};
GN Name=E2F2 {ECO:0000313|Ensembl:ENSMPUP00000015772.1,
GN ECO:0000313|RefSeq:XP_004741260.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000015772.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000015772.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004741260.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004741260.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; AEYP01008249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004741260.1; XM_004741203.3.
DR STRING; 9669.ENSMPUP00000015772; -.
DR Ensembl; ENSMPUT00000016013.1; ENSMPUP00000015772.1; ENSMPUG00000015878.1.
DR GeneID; 101678713; -.
DR KEGG; mpuf:101678713; -.
DR CTD; 1870; -.
DR eggNOG; KOG2577; Eukaryota.
DR GeneTree; ENSGT00940000160992; -.
DR HOGENOM; CLU_032091_0_0_1; -.
DR OMA; WVGRGIF; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR GO; GO:1990086; P:lens fiber cell apoptotic process; IEA:Ensembl.
DR GO; GO:1903671; P:negative regulation of sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF50; TRANSCRIPTION FACTOR E2F2; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 129..194
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 308..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..370
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 47924 MW; 260696A2EA1C736D CRC64;
MLRGPRALAP AAGPPSKGLH AMSPTELWPP GLSSPQLCPA TTTYYTSLYP QTVPPTAAPG
TCLDATPHGP EGQAVRCVPA GRLPAKRKLD LEGIGRPTVP EFRTPKGKCL RVDGLPSPRT
PKSPGEKTRY DTSLGLLTKK FIYLLSESKD GVLDLNWAAE VLDVQKRRIY DITNVLEGIQ
LIRKKAKNNI QWVGRGMFED PTRPGKQQQL GQELKELMSV EQALDQLIQS CSLSFKHLTE
DKANKRLAYV TYQDIRAVGN FKEQTVIAVK APPQTRLEVP DRSEENLQIY LKSTQGPIEV
YLCPEEVQEP DSPAKEPLLP TSTLGSSPDS TQPSSSTDPG MTEPVASPAP ALTPQQVPQP
PAPPPLPLVP LEATDSLLEL PHPLLQQTED QFLSPSLPCS SPLISFSPPL DQDDYLWGLD
GGEGISDLFD SYDLGDLLIN
//
