ID M3YYP2_MUSPF Unreviewed; 1877 AA.
AC M3YYP2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Cilia and flagella associated protein 65 {ECO:0000313|Ensembl:ENSMPUP00000016452.1};
DE SubName: Full=Cilia- and flagella-associated protein 65 isoform X1 {ECO:0000313|RefSeq:XP_004762850.1, ECO:0000313|RefSeq:XP_004762851.1};
GN Name=CFAP65 {ECO:0000313|Ensembl:ENSMPUP00000016452.1,
GN ECO:0000313|RefSeq:XP_004762850.1, ECO:0000313|RefSeq:XP_004762851.1,
GN ECO:0000313|RefSeq:XP_004762852.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016452.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004762850.1, ECO:0000313|RefSeq:XP_004762851.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004762850.1,
RC ECO:0000313|RefSeq:XP_004762851.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01056836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004762850.1; XM_004762793.3.
DR RefSeq; XP_004762851.1; XM_004762794.3.
DR RefSeq; XP_004762852.1; XM_004762795.3.
DR STRING; 9669.ENSMPUP00000016452; -.
DR Ensembl; ENSMPUT00000016697.1; ENSMPUP00000016452.1; ENSMPUG00000016555.1.
DR GeneID; 101693407; -.
DR KEGG; mpuf:101693407; -.
DR CTD; 255101; -.
DR eggNOG; ENOG502QSJW; Eukaryota.
DR GeneTree; ENSGT00430000031142; -.
DR HOGENOM; CLU_000944_1_0_1; -.
DR OMA; QQLKVMV; -.
DR OrthoDB; 5474981at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46127; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65; 1.
DR PANTHER; PTHR46127:SF1; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65; 1.
DR Pfam; PF15780; ASH; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000313|RefSeq:XP_004762850.1,
KW ECO:0000313|RefSeq:XP_004762851.1};
KW Cilium {ECO:0000313|RefSeq:XP_004762850.1,
KW ECO:0000313|RefSeq:XP_004762851.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000313|RefSeq:XP_004762850.1,
KW ECO:0000313|RefSeq:XP_004762851.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..367
FT /note="Abnormal spindle-like microcephaly-associated
FT protein ASH"
FT /evidence="ECO:0000259|Pfam:PF15780"
FT REGION 1665..1752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..1877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1726
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1877
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1877 AA; 211653 MW; 5CE5CFCDF1885C42 CRC64;
MLFQAAPSSL TQIRDSGDCT MNSGSCLSAS TAAMATITGS SVALSVCSSS NTSARPASLM
DTCVCFSKKR DKVKKRVIWG IEVAEVLQWK GWTLGKEVTK NLALKNVSLK TQKMVYRPPK
TKFFFTVIPL PILLSPGITF TLPIIFRPLE EKEYVDQLWF EKEEGMFYVD LRATLPRHSL
ICPPSLRLPM CAVGDTAEAW FCLENVGDLP TFFTWEFPSP FHILPTTGLL EPGQASYIKV
TFHPLLAILY EVQATCWYGE GSKQKSSIQL QAVAKCAQLL VSIKQKRPED QDAEGAQKVL
HFGTVAVGCT AERQIKLYNP SAVSAPFRIE VAPDVLAKDH TFSCPTTNGI VPPGGKKLVS
VSFHPETLDV RTIDYLSIMP SGCASQTLLK VVGFCRGPDV SLQHNCVNFS WVNLGQFSEQ
PLWIENKSDC TAYFQFAIDC QESVFGIRPA FGTLVGKARM TLHCAFRPTH PIIYSRRVAC
LIHHQDPLFL DLIGTCHSDS TKPAILRPQH LAWYRTHLAR GLTFYPPDIL STLLREKKLE
QDKNGALRIP TEDLADASSP KYPLISPMTE YFFDGTNDIA IFPPPVSIEP TEVDFGACPG
PENPNPVPLC LMNHTKGKIT VVWTHRSDCP FWVTPDTCSV PPLKSMAMRL HFHPPDPNCL
YAAELEAFAV YKVLQSYNNI EEDCTVCPSW CLTVHARGHS YRAALEHPVP QYSLHAPKLF
PAVSAGEPSY RSLLLINKGS MMLTFNLAPQ SSSDISLRPS SGLVAPRAHQ IFLICTYPKG
NCWKQHLFYL QFNFCPQYLK EVSMQSREEP LQLKLDTSKS VFFKPTWVGC SSTSLFTFRN
PSRLPLEFEW RISQPYGKIL AVQPVQGLIQ PSESITLTWT FSPLEETKYL FRVGMWVWEA
DLPPNTKPPA TTHYMLRLVG MGITSSLSVK EKELEFGNVL VNSKQSRSLK LLNDGNCTLY
YRLFLEQCSP QVVDNGPLAL QLDRTEGSLP PRSQDTICLT ACPHQRSQYC WKISYALLSH
RDNKAGKRQE LCCVFLMAVY PLLSILDVCP VGSAKGITRK HLWRLFSLDT LNSYLERDPT
PQELTYKVPT RHSTSQIPTV FTHLKLDFNF GAAPMEAPPS VVLLALKNRG VVSLDWAFLF
PSDQQIDLEL WAQQAEFDAT ELHQMRVQDN CVFSISPKAG SLSPGQEQVV ELKYSHVFIG
TDRLPVLFKV SHGREILLNF IGVTVKLEQK YVHFTSTSHE FVPVPIGNTL PPRQIYELYN
GGSVPVTYEI QTNILSQVQE KNFDHPVFCC LNPHGEIQPG TTAQVLWIFS PIEAKTYMVD
VPIHILGWNS AIIRFQGVGY DPQVMGDTAP FHNISSWDDH SIHSRLMVPG QNVVLSQSHI
SLGNIPVQSK CSRLLFLNNI SKSETIDFEW QLQPLEFGEV SVSPMTGKVA PEETIPFVVT
LKASVHASFY SMDLVCKVYR QKLLNQYRKE LQEWKDEEIR QEVEFTITDR KGKREEYCRA
CVPKRKYKTL PPIKSQQPLN RPVSWKLKIP KKKILWPRPQ PPSPGMLCLS LTARAHAPDD
FLANCSGFPQ HFLHRELPKR KYHKEEKLES SEEEAQDKWA PISKQEKQLL IDCLTTIIRG
LLEDKIFHEA VDQSLVEKMP YFCQFWNEQS AKITAQSNTL QLAPVLSPSS SSWEASRDKE
SEEDKLRRDK KVGEEEEESG EEEEELDEEE EEEEEIEEEE TGKGEQEEEA KEEKSSWTET
EPTLQPTSQE SLKWQWQQQL KVMVKEEQEQ DEKETISRLP AFANLQEALL ENMIQNILVE
ASRGEVVLTS RPRVIALPPL SPSRIETPDL LSAAPLGLQQ AEVSRLVVPP PSDSLRMPHP
SPADLRPSVP PSPLPGH
//
