ID M3YYR1_MUSPF Unreviewed; 861 AA.
AC M3YYR1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|RefSeq:XP_004775029.2};
DE SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSMPUP00000016471.1};
GN Name=PMS2 {ECO:0000313|Ensembl:ENSMPUP00000016471.1,
GN ECO:0000313|RefSeq:XP_004775029.2};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016471.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004775029.2}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004775029.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AEYP01085091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004775029.2; XM_004774972.3.
DR STRING; 9669.ENSMPUP00000016471; -.
DR Ensembl; ENSMPUT00000016716.1; ENSMPUP00000016471.1; ENSMPUG00000016574.1.
DR GeneID; 101675813; -.
DR KEGG; mpuf:101675813; -.
DR CTD; 5395; -.
DR eggNOG; KOG1978; Eukaryota.
DR GeneTree; ENSGT00940000155381; -.
DR HOGENOM; CLU_004131_0_2_1; -.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0032389; C:MutLalpha complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR GO; GO:0016447; P:somatic recombination of immunoglobulin gene segments; IEA:Ensembl.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Endonuclease {ECO:0000313|RefSeq:XP_004775029.2};
KW Hydrolase {ECO:0000313|RefSeq:XP_004775029.2};
KW Nuclease {ECO:0000313|RefSeq:XP_004775029.2};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 227..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 677..821
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 388..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 621..676
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 388..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 95784 MW; 27454492977E4173 CRC64;
MELAEGPSTE LAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSVDAG ATTIDLRLKD
YGVALIEVSD NGCGVEEDNF EGLTLKHHTS KIQDFADLTQ VETFGFRGEA LSSLCALSDV
TISTCHISAK VGTRLVFDHN GKIVQKTHHP RPRGTTVSVQ QLFHTLPVRH KEFQRNIKKE
YAKMVQVLHA YCIISAGIRV SCSNQVGPGR RQPVVCTSGS RSVKENIASV FGHKQLQSLI
PFVQLPPSDS ICEEFGLSQA DALRTLFHIS GFISYCAHGV GRSSTDRQFF FINGRPCDPA
KVSRLVNEVY HMYNRHQYPF VVLNISVDSE CVDINVTPDK RQILLQEEKL LLAILKTSLV
GMFDSDVNKL SVSQQPLLDV EGHLIKTHSA ETDKRQPEKQ DGATSLRTGG EEKRAVTISR
LRETFSLRHT AESRPQGPKS PELRRVSPRQ KRQERLPGAS DAPCTQKPIP GTDSCEPQEE
LMCSEKGPCD RRDRGDTEQD LGHSCLPADQ EEGLGAPETG HHTNRGFSQG SVASLEESPE
TDHHSADPED HFDQEDGGRT QRVLPGPADL SSSHTKRFKK DRIPSGSDAR QGPVKTQTSS
ASQVDVAVKI HKKIVPLAFS MRSLAHRIKQ LQQQEEQREA AQKCRKFRAK ICPGENQAAE
EELRKEISKA MFAEMEIIGQ FNLGFIITKL NADIFIVDQH ATDEKYNFEM LQQHTALQGQ
RLIAPQTLNL TAVNEAVLIE NLEIFRKNGF DFVIDEEAPV TERAKLISLP TSKNWTFGPQ
DIDELIFMLS DSPGVMCRPS RVRQMFASRA CRKSVMIGTA LSTSEMKKLI THMGEMDHPW
NCPHGRPTMR HIANLDVLSQ S
//
