ID M3YYY5_MUSPF Unreviewed; 420 AA.
AC M3YYY5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Mannose-1-phosphate guanyltransferase alpha {ECO:0000256|ARBA:ARBA00040222};
DE AltName: Full=GDP-mannose pyrophosphorylase A {ECO:0000256|ARBA:ARBA00042915};
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha {ECO:0000256|ARBA:ARBA00041992};
GN Name=GMPPA {ECO:0000313|Ensembl:ENSMPUP00000016545.1,
GN ECO:0000313|RefSeq:XP_004762931.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016545.1};
RN [1] {ECO:0000313|EMBL:AER99152.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AER99152.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
RN [2] {ECO:0000313|Ensembl:ENSMPUP00000016545.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004762931.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004762931.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May serve as a regulatory subunit and allow allosteric
CC feedback inhibition of GMPPB by GDP-mannose.
CC {ECO:0000256|ARBA:ARBA00037787}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; AEYP01056846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JP010555; AER99152.1; -; mRNA.
DR RefSeq; XP_004762931.1; XM_004762874.3.
DR STRING; 9669.ENSMPUP00000016545; -.
DR Ensembl; ENSMPUT00000016791.1; ENSMPUP00000016545.1; ENSMPUG00000016648.1.
DR GeneID; 101686125; -.
DR CTD; 29926; -.
DR eggNOG; KOG1460; Eukaryota.
DR GeneTree; ENSGT00940000157018; -.
DR HOGENOM; CLU_029499_3_0_1; -.
DR OMA; MPVPNWW; -.
DR OrthoDB; 5486038at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 3..195
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 420 AA; 46178 MW; 95A264FB3A1B841A CRC64;
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM QEILLIGFYQ
PDEALTRFLE AAQQEFNLPI RYLQEFVPLG TGGGLYHFRD QILAGGPEAF FVLNADVCSD
FPLTAMLDSY RHQPHPFLLL GTTANRTQSL NYGCIVENPQ THEVLHYVEK PSTFVSDIIN
CGIYLFSPEA LKPLRDVFQR NQQDGQLEDS SGLWPGAGTI RLEQDVFSAL AGQGQIYVHL
TDGIWSQIKS AGSALYASRL YLGQYQLTHP ERLAKHTPGG PRIRGNVYIH PTAKVAPSAV
LGPNVSIGEG VTVGEGVRLR ESIVLHGATL QEHTCVLHTI VGWGSTVGRW ARVEGTPNDP
NPNDPRAHMD SESLFKDGKL LPAITILGCR VRIPAEVLIL NSIVLPHKEL SRSFTNQIIL
//
