ID M3YZC2_MUSPF Unreviewed; 259 AA.
AC M3YZC2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST2 {ECO:0000313|Ensembl:ENSMPUP00000016682.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016682.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016682.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; AEYP01099062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01099063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01099064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01099065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01099066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01099067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YZC2; -.
DR STRING; 9669.ENSMPUP00000016682; -.
DR Ensembl; ENSMPUT00000016931.1; ENSMPUP00000016682.1; ENSMPUG00000016787.1.
DR eggNOG; KOG3704; Eukaryota.
DR GeneTree; ENSGT00940000160498; -.
DR HOGENOM; CLU_017703_0_0_1; -.
DR InParanoid; M3YZC2; -.
DR OMA; NIIFYRG; -.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; IEA:Ensembl.
DR GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF10; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 2; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 7..242
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 16
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 16..20
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 97
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 105
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 222..226
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 205..217
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 259 AA; 30179 MW; 65B28FDEFA7C8CF3 CRC64;
MGTKRLPQAL IVGVKKGGTR AVLEFIRVHP DVRALGTEPH FFDRNYGRGL DWYRSLMPRT
LESQITLEKT PSYFVTQEAP RRIFNMSRDT KLIVVVRNPV TRAISDYTQT LSKKPDIPTF
EGLSFRNRTL GQVDVSWSAI RIGMYALHLE SWLRYFPLAQ IHFVSGERLI TDPAGELGRV
QDFLGIKRFI TDKHFYFNKT KGFPCLRKTE SSLLPRCLGK SKGRTHVQID PEVIDQLREF
YRPYNIKFYE TVGQDFRWE
//
