ID M3YZT4_MUSPF Unreviewed; 601 AA.
AC M3YZT4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 8 {ECO:0000256|ARBA:ARBA00021754};
GN Name=KBTBD8 {ECO:0000313|Ensembl:ENSMPUP00000016845.1,
GN ECO:0000313|RefSeq:XP_004738381.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016845.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016845.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004738381.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004738381.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
CC -!- SIMILARITY: Belongs to the KBTBD8 family.
CC {ECO:0000256|ARBA:ARBA00006736}.
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DR EMBL; AEYP01002485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004738381.1; XM_004738324.3.
DR STRING; 9669.ENSMPUP00000016845; -.
DR Ensembl; ENSMPUT00000017094.1; ENSMPUP00000016845.1; ENSMPUG00000016949.1.
DR GeneID; 101677027; -.
DR KEGG; mpuf:101677027; -.
DR CTD; 84541; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158653; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR OMA; FWMYDHA; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR GO; GO:0014029; P:neural crest formation; IEA:Ensembl.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd18274; BTB_POZ_KBTBD8; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR028764; BTB/POZ_KBTBD8.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF433; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 49..117
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 68920 MW; 06855AF6A40CFB4B CRC64;
MAASADLSKS SPTPNGIPSS DTAHDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT
FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVVLTEANV
QALFTAASIF QIPSIQDQCA KYMISHLDPQ NSIGVFIFAD HYGHQELGDR SKEYIRKKFL
CVTKEQEFLQ LTKDQLISIL DSDDLNVDRE EHVYESIVRW FEHEQNEREV HLPEIFAKCI
RFPLMEEAFI EKIPPQFAQA IAKSYVEKGP SNTNGCTQRL GMTASEMIIC FDAAHKHSGK
KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF
WMYDHSTNRW LSKPPLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC
WTSVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYK
DSIYYIAGTC GNHQRMFTVE AYDIELNKWT RKKDFPCDES INPYLKLVLF QNKLHLFVRA
TQVTVEEHVF RTSRKNSLYQ YDDITDQWMK VYETPDRLWD LGRHFECAVA KLYPQCLQKV
L
//
