ID M3YZZ9_MUSPF Unreviewed; 417 AA.
AC M3YZZ9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Interleukin-5 receptor subunit alpha {ECO:0000313|Ensembl:ENSMPUP00000016910.1, ECO:0000313|RefSeq:XP_004738459.1};
GN Name=IL5RA {ECO:0000313|Ensembl:ENSMPUP00000016910.1,
GN ECO:0000313|RefSeq:XP_004738459.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016910.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004738459.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004738459.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AEYP01002772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004738459.1; XM_004738402.2.
DR RefSeq; XP_012909403.1; XM_013053949.1.
DR STRING; 9669.ENSMPUP00000016910; -.
DR Ensembl; ENSMPUT00000017161.1; ENSMPUP00000016910.1; ENSMPUG00000017016.1.
DR GeneID; 101674740; -.
DR KEGG; mpuf:101674740; -.
DR CTD; 3568; -.
DR eggNOG; ENOG502QZNV; Eukaryota.
DR GeneTree; ENSGT00940000160890; -.
DR HOGENOM; CLU_039945_0_0_1; -.
DR OMA; NKFRDPF; -.
DR OrthoDB; 5301668at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004914; F:interleukin-5 receptor activity; IEA:Ensembl.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0032674; P:regulation of interleukin-5 production; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF7; INTERLEUKIN-21 RECEPTOR; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_004738459.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158566"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..120
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 417 AA; 47134 MW; B7CE9B68F7B58B4E CRC64;
MASASLILLW AVVILRADSL PDKKSLLLPP TNFTINVTGL AQVLLRWEPN PHQEPGNVEL
GYRVRINAPQ EEDYETRNTE SKRVTVLHQG FSASVQTIPW DGHSLLASNW VSAELKAPPG
SPGTSIVNLT CTTTTMLNNS NPSRPYQVSL YCTWLVGKDA PEDTQYFFYY RYGSSTEECQ
EYRKDTLKRN IACWFPRTFI RSRGSDLLAV HANGSSQRAA IKPLDQLFAL HAIDRINPPV
NVTAEIEGNY LSIQWEKPIS AFPIHCFEYE VKIYNARKNY FQTEKMTTNT FISITDDISK
YSIQVRAAVS SVCRQTGLWS EWSQTVYVGN DDQKPSTEWF LIVLVATICF ILLIFTLICK
IGHLWARLFP PVPAPKNSLK DFLVIVSPEK TVSSETEIEV ISYVEESGLE TLEDSVF
//
