ID M3Z0L8_MUSPF Unreviewed; 1746 AA.
AC M3Z0L8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Plexin D1 {ECO:0000313|Ensembl:ENSMPUP00000017130.1};
GN Name=PLXND1 {ECO:0000313|Ensembl:ENSMPUP00000017130.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017130.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017130.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AEYP01003114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000017130; -.
DR Ensembl; ENSMPUT00000017384.1; ENSMPUP00000017130.1; ENSMPUG00000017238.1.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR InParanoid; M3Z0L8; -.
DR OMA; GHLCMWS; -.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0003279; P:cardiac septum development; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Ensembl.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR GO; GO:0008039; P:synaptic target recognition; IEA:Ensembl.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1093..1115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..368
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1746 AA; 193254 MW; 39834140EDBB4036 CRC64;
MLNVAANHPN ASTVGLVLPP AAGTGGSRLL VGATYTGYGS AFFPRNRSLE DHRFENTPEI
AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKERHKLG FVRAFLHPPD PPPGAPSYAY
LALNSEARAG DKESQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL
VSVFPARELL FAVFERPQGS PAARATPAAL CAFRFADVQA AIRAARNACF VEPAPDVVAV
LDSVVQGTGP ACERKRNIQL QPEQLDCGAA HLQHPLSILQ PLKATPVFRA PGLSSVAVAT
VSNYTVVFLG TVSGRLLKIN LNESMQVVSR RVVTVAYGEP VHHVMQFDPA DPGYLYLMTS
HQMARVKVAA CAVHATCGDC VGAADAYCGW CALETRCTLQ QDCANSDQPH FWTSASEGPG
RCPTMTVLPA EIDVHQEYPG MILQISGSLP SLSGMEMACD YGNDIRTVAR VPGPAFGHQI
AYCNLLPRAQ FPPFPPQQDH VIVEMSVRVN GRHIVRANFT IYDCGRVGQV YPHAACTSCL
SAQWPCFWCT QQHACVSNQS RCEASPNPTS PQDCPQILPS ALAPVPTGSS QSIPVRLANA
AFQGAALECS FGPEEIFEAM WVNESTVHCN QVVLHTTQKS QVFPLSLQLK GQPARYLDSP
APMTVEVYNC AMGSPDCSQC LGREDLGHLC VWSDGCRLRG PLQPLLGTCP APEIRVIEPL
SGPLDGGTLL TIRGRNLGRR LSDVAHGVWI GSVACEPLAD RYTVSEEIVC ATGPAPGAFS
DVVTVNASKE GKSRERFSYV LPLVQFLEPD KGPKAGGTRI TIHGSDLHVG SELQVLVNDT
EPCAELVRTD TSITCTVPEG TLPAPVSVCV RFEHRGCVRS NLTFHYMQNP VITAISPRRS
PVSGGRTITV AGERFHMVQN VSMAVHHIGR EPTLCKVLNS TLITCPSPGA LSNASAPVDF
FINGRAYADE VAVAEELLDP EEARRGGRFR LDYLPDPQFS TAKREKWIKH HPGEPLTLVI
HKEQDSLGLQ SHEYRIKIGQ VACDIQIVSD RVIHCSVNES LGTAEGQLPI TIQVGNFNQT
IATLQLGGSE TAIIVSIVIC SVLLLLSVVA LFVFCTKSRR AERYWQKTLL QMEEMESQIR
EEIRKGFAEL QTDMTDLTKE LNRSQGIPFL EYKHFVTRTF FPKCSSLYEE RYVLPSQTLN
SQGSSPVQET HPLLGEWKIP ESCRPNMEEG ISLFSSLLNN KHFLIVFVHA LEQQKDFAVR
DRCSLASLLT IALHGKLEYY TGIMKELLVD LIDASAAKNP KLMLRRTESV VEKMLTNWMS
ICMYSCLRET VGEPFFLLLC AIKQQINKGS IDAITGKARY TLNEEWLLRE NIEAKPRNLN
VSFQGCGMDS LSVRAMDTDT LTQVKEKILE AFCKNVPYSQ WPRAEDVDLE WFASSTQSYI
LRDLDDTSVV EDGRKKLNTL AHYKIPEGAS LAMSLTDKKD NTLGRVKDLD TEKYFHLVLP
TDELAEPKKS HRQSHRKKVL PEIYLTRLLS TKGTLQKFLD DLFKAILSIR EDKPPLAVKY
FFDFLEEQAE KRGISDPDTL HIWKTNSLPL RFWVNILKNP QFVFDIDKTD HIDACLSVIA
QAFIDACSIS DLQLGKDSPT NKLLYAKEIP EYRKIVQRYY KQIHDMTPLS EQEMNAHLAE
ESRKYQNEFN TNVAMAEIYK YAKRYRPQIM TALEANPTAR RTQLQHKFEQ VVALMEDNIY
ECYSEA
//
