ID M3Z135_MUSPF Unreviewed; 432 AA.
AC M3Z135;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Cyclin-A2 {ECO:0000256|ARBA:ARBA00019673};
GN Name=CCNA2 {ECO:0000313|Ensembl:ENSMPUP00000017297.1,
GN ECO:0000313|RefSeq:XP_004748041.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017297.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004748041.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004748041.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01023601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004748041.1; XM_004747984.3.
DR STRING; 9669.ENSMPUP00000017297; -.
DR Ensembl; ENSMPUT00000017553.1; ENSMPUP00000017297.1; ENSMPUG00000017407.1.
DR GeneID; 101677173; -.
DR KEGG; mpuf:101677173; -.
DR CTD; 890; -.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00940000155372; -.
DR HOGENOM; CLU_020695_3_2_1; -.
DR OMA; HQPFSIH; -.
DR OrthoDB; 5474295at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0097122; C:cyclin A2-CDK1 complex; IEA:Ensembl.
DR GO; GO:0097124; C:cyclin A2-CDK2 complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0001939; C:female pronucleus; IEA:Ensembl.
DR GO; GO:0001940; C:male pronucleus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0044843; P:cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0043687; P:post-translational protein modification; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR CDD; cd20561; CYCLIN_CCNA2_rpt1; 1.
DR CDD; cd20564; CYCLIN_CCNA2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR032447; Cyclin-A_N.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR046965; Cyclin_A/B-like.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR PANTHER; PTHR10177:SF444; CYCLIN-A2; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF16500; Cyclin_N2; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 216..300
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 309..427
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 313..396
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48532 MW; 7259D7ACBEF8F88E CRC64;
MLGSSEPGPA AREAGSSLLT LQHTALQEDQ ENINPEKAAP AQQPRTRAGL AVLKAGNPRV
PAPQQRPKTR RVAPLKDLPV NDEHVTVPPW KANSKQPAFT IHVDEAEQET QKRPAEPKKT
EHENVLAFNS AITLPGPRKP LVPLDYPMDG SFESPHTMDI SIVLEDEKPL SVNEVPDYHE
DIHTYLREME VKCKPKVGYM KKQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID
RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYTKKQ VLRMEHLVLK
VLAFDLAAPT VNQFLTQYFL HQHSANCKVE SLAMFLGELS LIDADPYLKY LPSVIAAAAF
HLALYTVTGQ SWPESLVQKT GYTLESLKPC LMDLHQTYLR APQHAQQSIR EKYKSSKYHG
VSLLNPPETL NV
//
