ID M3Z200_MUSPF Unreviewed; 1372 AA.
AC M3Z200;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G2 {ECO:0000313|Ensembl:ENSMPUP00000017612.1};
GN Name=PLEKHG2 {ECO:0000313|Ensembl:ENSMPUP00000017612.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017612.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017612.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01088720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000017612; -.
DR Ensembl; ENSMPUT00000017871.1; ENSMPUP00000017612.1; ENSMPUG00000017723.1.
DR eggNOG; KOG3518; Eukaryota.
DR GeneTree; ENSGT00940000162093; -.
DR HOGENOM; CLU_007452_0_0_1; -.
DR InParanoid; M3Z200; -.
DR OMA; EPMKDPY; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 102..283
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 313..411
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1318
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1372 AA; 146696 MW; A68B09884B191E83 CRC64;
MPEGARGPNL SKPSPSLGRG PTGEVCDCAA VCESQTGPAT PAMASPRGSG SSTSLSTVGS
EGDPAPGPTP VCSASRPEPL PGPPIRLHLS PVGTPGLAKP SRLERVVREI VETERAYVRD
LRSIVEDYLA PLMDGGVLGL SAEQVGMLFA NIEDIYEFSS ELLEDLEGSS SAGGIAECFV
QRSEDFDIYT LYCMNYPSSL ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI
LKYHLLLQEL GKHWAEGPGA GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL
GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR GPEYTYKGHI
FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA
KAKQVLLENS LHCAPKSKPI PEPLTPPLGS PRPRDARSFT PGRRNTAPSP GPSATRRGRR
QSEPVKEPYV MFPPNAKPRL KHTGSEGELY PPLEPQPPVP TSGPPEDLED TGPPTLEPSG
TSITEEILEL LNQRGLRDPG PSPHDIPKFS GDSQVPGDSE TLTFRALPSR DSSEEEEEEE
LEMDERGPSP LHVLEGLESS SAAETTDVSG LSKSPDAPGL PEIPGLSEIP KIPHLPSLSD
ISSVFEMPRL PAIPNVPDIP SLASTPALPC DSWLQGPLQG PDEAVATRRE LFPGGSSAKL
GEPSSGGRAG QEEPEEGEPF PDFQPQDVPQ DQGFPDELEF RSCSEIRSAW RALEQGQLAR
PGFPEPLLIL EDSDLGGGSG SRKAGAPSSE RAASRVRELA RLYSERIQQM QRAETRASAN
APRRRPRALA QPQLSPRLPQ EHAEPVHTGP LPAFGHVLVC ELAFPLTCAQ ESVPLGPAAR
VQAATPLSKQ GGCPGGRGLS VSSLPEEDHL GIRVPAARRL SEQGDPQNIQ SMTVSTTALP
PQEDPPDVQV LATALPDPGG HLEVQHPATT PLPQHRGHMD TQVPTSPALP GQRCCPDVTV
LATATVPKQE GPLHSQSPSN TPLTRQGGPR DVPFLAGVGN QAVDISLTHG SSLDRPIPGN
AALPSQHDLP DNIQFLGTSS LPAHECCLDH QLPASTALSL PQNSNVPAAA PLPQRPGLPD
TQVQALPPLP KQGGLPDTQG PSATPLLQEQ SFTDLQIQKR SPLEQRSLSD VRGPAPTLLP
EQRGSRDSQG LFSTPAQTTM VLSKPGHYLA SPVTRSESSE LTPPHSPPLP TRQLLGPNAA
ALSRYLAASY ISQSLARRQG SGGEAPLASR GPWSSSAPAS RAPSPPPQPQ PPPPPARRLS
YATTVNIHVG GGGRLRPAKA QVRLNHPALL APAHESVGLR RAQGAPDAPF HM
//
