ID M3Z2T1_MUSPF Unreviewed; 328 AA.
AC M3Z2T1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=WD repeat and FYVE domain containing 2 {ECO:0000313|Ensembl:ENSMPUP00000017893.1};
GN Name=WDFY2 {ECO:0000313|Ensembl:ENSMPUP00000017893.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017893.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; AEYP01085944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01085945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01085946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01085947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01085948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01085949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Z2T1; -.
DR STRING; 9669.ENSMPUP00000017893; -.
DR Ensembl; ENSMPUT00000018154.1; ENSMPUP00000017893.1; ENSMPUG00000018004.1.
DR eggNOG; KOG1409; Eukaryota.
DR GeneTree; ENSGT00940000158527; -.
DR HOGENOM; CLU_046919_0_0_1; -.
DR InParanoid; M3Z2T1; -.
DR OMA; DYNQITH; -.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd15718; FYVE_WDFY1_like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; LD41958P; 1.
DR PANTHER; PTHR46189:SF3; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT REPEAT 122..155
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 165..206
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 209..280
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REPEAT 290..323
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 328 AA; 36952 MW; 419EBAA42522D959 CRC64;
MSFNPETRRL SIGLDNGTIA EFILSEDYNK MTPVKNYQAH QSRVTMILFV LELEWVLSTG
QDKQFAWHCS ESGQRLGGYR TSAVASGLQF DVETRHVFIG DQSGQVTILK LEQDSCTLVT
TFRGHTGGVT ALCWDPVQRV LFSGSSDHSV IMWDIGGRKG TAIELQGHND KVQALSYAQH
TRQLISCGGD GGIVVWNMDV ERQEKTPEWL DSDSCQKCDQ PFFWNFKQMW DSKKIGLRQH
HCRKCGKAVC GKCSSKRSSI PLMGFEFEVR VCDSCHEAIT DEERAPTATF HDSKHNIVHV
HFDATRGWLL TSGTDKVIKL WDMTPVVS
//
