ID M3Z3G7_MUSPF Unreviewed; 760 AA.
AC M3Z3G7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A3 {ECO:0000313|Ensembl:ENSMPUP00000018129.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018129.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AEYP01005320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Z3G7; -.
DR STRING; 9669.ENSMPUP00000018129; -.
DR Ensembl; ENSMPUT00000018395.1; ENSMPUP00000018129.1; ENSMPUG00000018243.1.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; M3Z3G7; -.
DR OMA; ALYWIPK; -.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 105..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 128..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 255..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 371..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 465..493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 521..716
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 760 AA; 84210 MW; 0CD6BACEF87CE003 CRC64;
MIEPIGNQYV VARPVYSANN LSISEHSEMR AEESSQLKCC KSQANCSTQK AKKIALSLFP
IASWLPTYQI KEWLLSDIVS GISTGLVAVL QGLAFALLVT VPPSYGLYAA FFPVLVYFFL
GTSKHISVGP FPVLSMMVGA VVVKLTPSES TAALEISNSS MSNDSSTDEY KVMVAATVTV
LSGIIQLLMG VLRVGFLVIY LSESLISGFT TAAAVHVLVS QLKFMLQLTV PAHTDPFSIF
KVLNSVFTQI EKTNIADLVT SLIILVIVFV VKEINQRYKA KLPVPIPIEL IMTVIATGVS
YGFDFENRFK VAVVGEMKRG FQPPIAPDTQ IFQETIGDSF GIAIVGFVVA FSVASVYSLK
YDYPIDGNQE LIALGLSNIF SGSFQGFAGS TALSRSGVQE STGGKTQIAG ILSAIIVLIV
ILALGFLLEP LQKSVLAALA LGNLKGMLMQ FTEIRRLWRK DKYDCLIWIM TFIFAIVLGL
GLGLAASVAF QLLTIVFRTQ FPKCSTLANV GRSNIYKNKK DYSDMYEPEG VKIFRCPAPI
YFANIHFFKQ KLIDAVGFNP LRILRKRNKA LKKIRKLQKK GLLQVTPKGF ICTNDGFKDS
DDELDNNEIE ELDQPIHTSD LPFQIDWNAD LPLNMVVPQI SLHSLILDFS AVSFLDISSM
RGLKTILQEF IRINVDVYIV GSDDDFIEKL VQCEFFDDEV KDSIFFLTIH DAVLHIWMTK
DYNASKFNAS QEKEMKFDFT INTNGGLRNR ECQVPVETKF
//