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Database: UniProt
Entry: M3Z3G7_MUSPF
LinkDB: M3Z3G7_MUSPF
Original site: M3Z3G7_MUSPF 
ID   M3Z3G7_MUSPF            Unreviewed;       760 AA.
AC   M3Z3G7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A3 {ECO:0000313|Ensembl:ENSMPUP00000018129.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018129.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000018129.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; AEYP01005320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3Z3G7; -.
DR   STRING; 9669.ENSMPUP00000018129; -.
DR   Ensembl; ENSMPUT00000018395.1; ENSMPUP00000018129.1; ENSMPUG00000018243.1.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; M3Z3G7; -.
DR   OMA; ALYWIPK; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR   GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR   GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        78..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        105..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        128..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        196..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        255..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        340..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        371..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        465..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          521..716
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   760 AA;  84210 MW;  0CD6BACEF87CE003 CRC64;
     MIEPIGNQYV VARPVYSANN LSISEHSEMR AEESSQLKCC KSQANCSTQK AKKIALSLFP
     IASWLPTYQI KEWLLSDIVS GISTGLVAVL QGLAFALLVT VPPSYGLYAA FFPVLVYFFL
     GTSKHISVGP FPVLSMMVGA VVVKLTPSES TAALEISNSS MSNDSSTDEY KVMVAATVTV
     LSGIIQLLMG VLRVGFLVIY LSESLISGFT TAAAVHVLVS QLKFMLQLTV PAHTDPFSIF
     KVLNSVFTQI EKTNIADLVT SLIILVIVFV VKEINQRYKA KLPVPIPIEL IMTVIATGVS
     YGFDFENRFK VAVVGEMKRG FQPPIAPDTQ IFQETIGDSF GIAIVGFVVA FSVASVYSLK
     YDYPIDGNQE LIALGLSNIF SGSFQGFAGS TALSRSGVQE STGGKTQIAG ILSAIIVLIV
     ILALGFLLEP LQKSVLAALA LGNLKGMLMQ FTEIRRLWRK DKYDCLIWIM TFIFAIVLGL
     GLGLAASVAF QLLTIVFRTQ FPKCSTLANV GRSNIYKNKK DYSDMYEPEG VKIFRCPAPI
     YFANIHFFKQ KLIDAVGFNP LRILRKRNKA LKKIRKLQKK GLLQVTPKGF ICTNDGFKDS
     DDELDNNEIE ELDQPIHTSD LPFQIDWNAD LPLNMVVPQI SLHSLILDFS AVSFLDISSM
     RGLKTILQEF IRINVDVYIV GSDDDFIEKL VQCEFFDDEV KDSIFFLTIH DAVLHIWMTK
     DYNASKFNAS QEKEMKFDFT INTNGGLRNR ECQVPVETKF
//
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